宁泌泰胶囊联合左氧氟沙星治疗细菌性前列腺炎的临床疗效  

Clinical efficacy of Ningmitai Capsules combined with levofloxacin in treatment of bacterial prostatitis

作　　者：周睿 朱劲松 陈志洁 鲍彤 ZHOU Rui;ZHU Jinsong;CHEN Zhijie;BAO Tong(Anqing Affiliated Hospital of Anhui Medical University(Anqing Municipal Hospital),Anqing 246003,China)

机构地区：[1]安徽医科大学附属安庆医院(安庆市立医院),安徽安庆246003

出　　处：《药物评价研究》2021年第2期403-406,共4页Drug Evaluation Research

摘　　要：目的宁泌泰胶囊联合左氧氟沙星治疗细菌性前列腺炎的临床疗效。方法选取2018年1月—2019年9月安徽医科大学安庆附属医院收治的62例细菌感染性前列腺炎患者作为研究对象,根据治疗方案的不同将患者分为对照组和观察组,每组31例。对照组患者静脉滴注盐酸左氧氟沙星注射液,0.4 g/d;观察组在对照组基础上口服宁泌泰胶囊,3粒/次,3次/d。两组患者均治疗2周。观察两组患者的临床疗效,同时比较两组治疗前后尿液、前列腺液中白细胞数量和美国国立卫生研究院前列腺炎症状指数(NIH-CPSI)评分。结果治疗后,观察组总有效率为93.54%,显著高于对照组的77.42%,差异具有统计学意义(P<0.05)。治疗后,两组尿液和前列腺液白细胞数量显著下降,差异具有统计学意义(P<0.01);观察组治疗后尿液和前列腺液白细胞数量显著低于对照组,差异具有统计学意义(P<0.01)。两组患者治疗后NIH-CPSI评分均显著下降,差异具有统计学意义(P<0.05);治疗后,观察组NIH-CPSI评分显著低于对照组,差异具有统计学意义(P<0.05)。治疗过程中,观察组恶心呕吐、腹痛腹泻发生例数均显著低于对照组,差异具有统计学意义(P<0.05)。结论宁泌泰胶囊联合左氧氟沙星治疗细菌性前列腺炎具有较好的临床疗效,不良反应发生率较低,值得临床推广。Objective To investigate the clinical efficacy of Ningmitai Capsules combined with levofloxacin in treatment of bacterial infectious prostatitis.Methods A total of 62 patients with bacterial prostatitis admitted to Anqing Affiliated Hospital of Anhui Medical University from January 2018 to September 2019 were selected as the study subjects.According to different treatment regiments,the patients were divided into control group and observation group,with 31 patients in each group.Patients in the control group were intravenously injected with Levofloxacin Hydrochloride Injection,0.4 g/d.Patients in the observation group were po administered with Ningmitai Capsules on the basis of control group,3 tablets/time,three times daily.Patients in two groups were treated for two weeks.The clinical efficacy in two groups was observed,and the count of white blood cells in urine and prostatic fluidwhite,and NIH-CPSI score before and after treatment in two groups were compared.Results After treatment,the total effective rate of the control group was 93.54%,which was significantly higher than 77.42%of control group,with statistically significant difference(P<0.05).After treatment,the number of white blood cells in urine and prostatic fluid of two groups was significantly decreased(P<0.01).After treatment,the number of white blood cells in urine and prostatic fluid in the observation group was significantly lower than those in the control group,and the difference was statistically significant(P<0.01).After treatment,NIHCPSI scores were significantly decreased in two groups,and the difference was statistically significant(P<0.05).After treatment,the NIH-CPSI score in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).During the treatment,the number of nausea and vomiting,abdominal pain and diarrhea in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Ningmit

关 键 词：宁泌泰胶囊 左氧氟沙星 细菌性前列腺炎 白细胞数量 美国国立卫生研究院前列腺炎症状指数评分 不良反应 

分 类 号：R983[医药卫生—药品]