生血宁片辅助治疗妊娠期贫血的系统评价  

Systematic review of Shengxuening Tablet in adjuvant treatment of gestational anemia

作　　者：蒋秋霞 王甜 王金权 刘金响 田淼[2] 朱丽红[2] JIANG Qiuxia;WANG Tian;WANG Jinquan;LIU Jinxiang;TIAN Miao;ZHU Lihong(Shanxi University of Traditional Chinese Medicine,Jinzhong 030619,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China;Shanxi Hospital of Traditional Chinese Medicine Shanxi Jinzhong,Jinzhong 030012,China)

机构地区：[1]山西中医药大学,山西晋中030619 [2]陕西中医药大学第二附属医院,陕西咸阳712000 [3]山西省中医医院,山西晋中030012

出　　处：《药物评价研究》2021年第2期407-414,共8页Drug Evaluation Research

基　　金：国家自然科学基金面上项目(81774133);陕西省教育厅科研课题资助项目(20JK0604);陕西省中医药管理局科研课题资助项目(LCMSO15);陕西省自然科学资助项目(806215973013);咸阳市科学技术资助项目(2017k02-88、2017k02-87)。

摘　　要：目的系统评价生血宁片辅助治疗妊娠期贫血的临床疗效和安全性。方法检索中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文期刊全文数据库(VIP)、万方数据库、PubMed、Embase、Cochrane Library等数据库,时间为建库至2020年7月30日,筛选生血宁片辅助治疗妊娠期贫血的随机对照试验(RCTs)。采用RevMan 5.3软件对纳入的研究进行Meta分析,采用Cochrane系统工具评价文献质量。结果共纳入10篇RCTs,1208例患者。Meta分析结果示,生血宁片辅助治疗妊娠期贫血可以提高治疗总有效率[RR=1.20,95%CI=(1.14,1.26)];红细胞水平[SMD=2.08,95%CI=(1.51,2.60)]、血红蛋白水平[SMD=1.91,95%CI=(1.51,2.31)]、转铁蛋白水平[SMD=2.12,95%CI=(1.95,2.29)]、血清铁水平[SMD=2.67,95%CI=(1.88,3.45)]均有一定的升高作用,同时可以减少不良反应的发生[RR=0.17,95%CI=(0.08,0.38)],所有结果与对照组比较均有统计学意义(P<0.05)。结论生血宁片辅助治疗妊娠期贫血可有效提高患者的总有效率,改善患者症状,提高患者红细胞、血红蛋白、转铁蛋白水平及血清铁水平,降低不良反应发生率。但纳入文献质量较低,存在一定发表偏倚,仍需要更多大样本、高质量的临床试验加以验证。Objective To evaluate the clinical efficacy and safety of Shengxuening Tablet in adjuvant treatment of gestational anemia.Methods Data was retrieved from CNKI,VIP,Wanfang,CBM,PubMed,Embase,Cochrane Library and other databases until the 30th July 2020.Screening a randomized controlled trial(RCT)of Shengxuening Tablet in the adjuvant treatment of anemia in pregnancy.Meta-analysis was conducted on the included studies using RevMan 5.3 software,and Cochrane systematic evaluation tool was used to evaluate literature publication bias.Results A total of 10 RCTs and 1208 patients were included.Meta-analysis results showed that Shengxuening Tablet adjuvant treatment gestational anemia could improve the total effective rate[RR=1.20,95%CI=(1.14,1.26)].It has a certain effect on the increase of red blood cell level[SMD=2.08,95%CI=(1.51,2.60)],hemoglobin level[SMD=1.91,95%CI=(1.51,2.31)],transferrin level[SMD=2.12,95%CI=(1.95,2.29)]and serum iron level[SMD=2.67,95%CI=(1.88,3.45)],and can reduce the incidence of adverse reactions in patients[RR=0.17,95%CI=(0.08,0.38)],all results were statistically significant(P<0.05).Conclusion Shengxuening Tablet in adjuvant treatment of pregnancy anemia can effectively improve the total effective rate and improve the symptoms of patients;increase the level of red blood cell,hemoglobin,transferrin and serum iron,and reduce the incidence of adverse reactions.However,the quality of the included literature is low,and there is a certain publication bias,which still needs to be verified by more large samples and high-quality experimental data.

关 键 词：生血宁片 贫血 妊娠期贫血 META分析 

分 类 号：R287.4[医药卫生—中药学]