新型α-葡萄糖苷酶抑制剂筛选及药理作用研究进展  

Research progress of screen and pharmacological effect for novel α-glucosidase

作　　者：阎成炟 郭崇真 林建阳[1,2] YAN Chengda;GUO Chongzhen;LIN Jianyang(Department of Pharmacy,The First Affiliated Hospital of China Medical University,Shenyang 110001,China;College of Pharmaceutical Science,China Medical University,Shenyang 110122,China)

机构地区：[1]中国医科大学附属第一医院药学部,辽宁沈阳110001 [2]中国医科大学药学院,辽宁沈阳110122

出　　处：《药物评价研究》2021年第2期440-445,共6页Drug Evaluation Research

基　　金：国家自然基金青年科学基金资助项目(81302841);辽宁省高等学校优秀人才支持计划(LJQ2014086)。

摘　　要：α-葡萄糖苷酶抑制剂能有效降低餐后血糖,为临床一线降糖用药之一。近年来报道了大量新化合物作为α-葡萄糖苷酶抑制剂,不仅可以起到降糖的作用,而且还具有抗溶酶体堆积病、抗病毒、抗菌和抗癌的药效。α-葡萄糖苷酶抑制剂新型化合物按照产出途径主要有微生物代谢产物、天然产物与化学合成产物。就近年来开发的多种类型的α-葡萄糖苷酶抑制剂及其抗癌、抗病毒和抗溶酶体堆积病作用进行了综述,旨在为α-葡萄糖苷酶抑制剂或临床前候选药物提供更好的研究方向。Alpha-glucosidase inhibitor is one of the first-line antidiabetic medication which could reduce postprandial blood glucose effectively. In recent years, a substantial number of new compounds have been reported as alpha-glucosidase inhibitors, have multiple physiological effects including hypoglycemic effects, anticancer, antiviral, and anti-lysosomal storage disorders effect. The main types of new alpha-glucosidase inhibitor are microbial metabolites, natural products and chemically synthesized products. This review presents the various types of alpha-glucosidase inhibitors developed in recent years and its pharmacological effects, aimed to provide guidance to alpha-glucosidase inhibitors or clinical candidates.

关 键 词：Α-葡萄糖苷酶抑制剂 2型糖尿病 作用机制 药理作用 抗病毒 抗溶酶体堆积病 

分 类 号：R977.1[医药卫生—药品]