Et_(3)N-Catalyzed Cycloaddition Reactions ofα-(Trifluoromethyl)styrenes with 2,2,2-Trifluorodiazoethane to Access Bis(trifluoromethyl)-Substituted Pyrazolines  

作　　者：Chunmei Li Xuxue Zhang Jingjing He Sixue Xu Song Cao 

机构地区：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai,200237 China [2]College of Chemistry and Chemical Engineering,Qilu Normal University,Jinan,Shandong,250200 China

出　　处：《Chinese Journal of Chemistry》2021年第2期301-306,共6页中国化学（英文版）

基　　金：support from the National Key Research and Development Program of China(No.2017YFD0200505)。

摘　　要：A novel and practical method for the synthesis of 3,5-bis(trifluoromethyl)-4,5-dihydro-1H-pyrazoles by [3+2] cycloaddition reactions of α-(trifluoromethyl)styrenes with 2,2,2-trifluorodiazoethane (CF3CHN2) has been developed. The cyclization reaction proceeds smoothly in the presence of a catalytic amount of Et_(3)N, affording a variety of bis(trifluoromethyl)-substituted 2-pyrazolines in good to excellent yields. This method also exhibits a broad substrate scope and tolerates various functional groups.

关 键 词：Cycloaddition 2 2 2-Trifluorodiazoethane α-(Trifluoromethyl)styrenes PYRAZOLINE Et_(3)N-catalyzed 

分 类 号：O626.24[理学—有机化学]