Metal-Organic Frameworks-Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo  

作　　者：Meijia Liu Xiangling Ren Xianwei Meng Hongbo Li 

机构地区：[1]Experimental Center of Advanced Materials,School of Materials Science&Engineering,Beijing Institute of Technology,Beijing,100081 China [2]Laboratory of Controllable Preparation and Application of Nanomaterials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190 China

出　　处：《Chinese Journal of Chemistry》2021年第2期473-487,共15页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.21701015,61975214,21811530054,61671435);the Bejing Natural Science Foundation(No.4202075);the National Key R&D Program(2018YFC0115500).

摘　　要：Metal-organic frameworks(MOFs)as a class of porous functional materials have attracted more and more attention for biomedical applications.To date,MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas,high porosity,fluorescence functionalities and good biocompatibility.It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes,quantum dots,metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function.Importantly,excellent imaging capabilities are of great significance in living cells and in vivo for detection,diagnosis and cancer therapy.In this review,we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF-based nanocomposites and their potential biological clinical applications.

关 键 词：Metal-organic frameworks Fluorescent material NANOSTRUCTURES FLUORESCENCE BIOIMAGING 

分 类 号：O64[理学—物理化学]