黄芪主要活性成分对糖尿病肾病的疗效机制研究进展  

Research progress of the curative effects of main active components of Astragalus membranaceus in treatment of diabetic nephropathy

作　　者：倪慧明 董哲毅[2] 陈香美 Ni Hui-Ming;Dong Zhe-Yi;Chen Xiang-Mei(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Department of Nephrology,Chinese PLA General Hospital/Chinese PLA Institute of Nephrology/State Key Laboratory of Kidney Diseases/National Clinical Medicine Research Center for Chronic Kidney Diseases/Beijing Key Laboratory of Kidney Diseases,Beijing 100853)

机构地区：[1]广东药科大学中药学院,广州510006 [2]解放军总医院肾脏病科/解放军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心/肾脏疾病研究北京市重点实验室,北京100853

出　　处：《解放军医学杂志》2021年第3期294-299,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81700629);国家重点研发计划(2016YFC1305503,2018YFC1704203);北京市科技计划(D171100002817002)。

摘　　要：糖尿病肾病(DN)是糖尿病的常见并发症,是最终导致终末期肾病(ESRD)的主要原因之一。目前,由于DN的发病机制尚未明确,所以缺乏有效的治疗措施。黄芪作为我国的传统中药材,常用于DN的治疗。黄芪中含有黄芪甲甙(AS-Ⅳ)及黄芪多糖(APS)两种主要活性成分,可有效减轻蛋白尿,保护肾脏功能。该文从调节内质网应激(ERS)、抗炎、减少细胞凋亡、抑制纤维化、调节糖脂代谢等方面对AS-Ⅳ及APS治疗DN的机制进行综述,为其进一步应用于DN的临床治疗提供依据。Diabetic nephropathy(DN)is a common complication of diabetes,and is one of the main causes of end stage renal disease(ESRD).At present,the practical therapeutic method for DN is still lacked due to unclear pathogenesis.However,as a traditional Chinese medicine,astragalus,especially Astragalus membranaceus,is commonly used in the treatment of DN.The main active ingredients of Astragalus membranaceus include astragalosideⅣ(AS-Ⅳ)and astragalus polysaccharide(APS),which can effectively reduce proteinuria and protect renal function.The mechanism of AS-Ⅳand APS in treatment of DN was reviewed in present article including regulation of endoplasmic reticulum stress(ERS),anti-inflammatory,reducing cell apoptosis,inhibiting fibrosis,and regulating metabolism of sugar and lipid,in order to provide reference for the research and clinical application.

关 键 词：糖尿病肾病 黄芪甲甙 黄芪多糖 

分 类 号：R587.1[医药卫生—内分泌]