沙眼衣原体和解脲脲原体双重感染对男性精液质量各参数的影响分析  

Influence of Chlamydia trachomatis and Ureaplasma urealyticum infection on semen quality

作　　者：王鲁娟 茅利明 WANG Lujuan;MAO Liming(Department of Laboratory,Maternal and Child Health Hospital of Fenghua District,Ningbo 315500,China)

机构地区：[1]宁波市奉化区妇幼保健院检验科,浙江宁波315500 [2]绍兴市中心医院检验科

出　　处：《全科医学临床与教育》2021年第3期244-246,共3页Clinical Education of General Practice

摘　　要：目的探讨引起非淋球菌性生殖道感染的沙眼衣原体(CT)、解脲脲原体(UU)等病原微生物对男性精液相关成分的影响关系。方法选择精液常规检查,且经实时荧光定量PCR法检测CT和UU均阳性的育龄青年男性患者46例为混合感染组,选择同期在本院进行婚前精液检查的正常健康男性64例为对照组。分析两组精液的计算机辅助精液分析结果。结果混合感染组精液中的液化时间、pH值、异常精子畸形率高于对照组,精子浓度、精子活动率和精子活力均低于对照组,差异均有统计学意义(t分别=7.17、2.10、8.79、-7.96、-11.60、-6.59,P均<0.05)。混合感染组精液中的动态参数曲线速率(VCL)、直线速率(VSL)、平均路径速率(VAP)、侧摆幅度(ALH)、平均移动角度(MAD)和鞭打频率(BCF)均低于对照组,差异均有统计学意义(t分别=-12.55、-13.55、-18.99、-7.49、-5.01、-6.41,P均<0.05)。结论泌尿生殖道CT和UU感染会影响男性精液常规质量和精子形态学参数,其对精子形态和活力的影响,造成男性精液质量下降。Objective To discuss the relationship between chlamydia trachomatis and ureaplasma urealyticum which caused non-gonococcal urethritis and relevant parameters of sperm.Methods The 46 males whose CT and UU were positive diagnosed by RT-PCR were enrolled as mixed infection group and 64 normal healthy males were selected as control group.The semen dynamic analysis was performed.Results Compared with the control group,the liquefying time,pH value,abnormal sperm malformation rate in mixed infection group were higher,while the sperm concentration,sperm motility rate,sperm motility were lower(t=7.17,2.10,8.79,-7.96,-11.60,-6.59,P<0.05).The dynamic parameters such as VCL,VSL,VAP,ALH,MAD,and BCF of mixed infection group significantly lower than those of the control group(t=-12.55,-13.55,-18.99,-7.49,-5.01,-6.41,P<0.05).Conclusion The chlamydia trachomatis and ureaplasma urealyticum infection could influence the quality of the sperm and the sperm dynamic parameters.It lead to the quality descend of the sperm by influencing the sperm form and activity.

关 键 词：非淋球菌性尿道炎 沙眼衣原体 解脲脲原体 实时荧光定量-PCR 精液 

分 类 号：R695[医药卫生—泌尿科学]