核酸识别模式识别受体在糖尿病中的作用研究进展  

Advances in the role of nucleic acid recognition pattern recognition receptor indiabetes mellitus

作　　者：刘英奇 谢璐 刘雨霞 周娟 刘志平[2,3] LIU Ying-qi;XIE Lu;LIU Yu-xia;ZHOU Juan;LIU Zhi-ping(Gannan Medical University;School of Basic Medicine of Gannan Medical University;Center for Immunology of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院基础医学院 [3]赣南医学院炎症与免疫中心,江西赣州341000

出　　处：《赣南医学院学报》2021年第2期189-194,218,共7页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(31960163);江西省自然科学基金项目(20171ACB20024,20181BAB205032)。

摘　　要：糖尿病在全球的发病率日益增长,由它引起的各种并发症(糖尿病性肾病综合症,糖尿病性心肌病等)所导致的死亡率也日益增多。模式识别受体(PRRs)能启动先天性免疫应答,清除相关病原体从而维持机体稳态,与糖尿病的发生发展有着密切的联系。PRRs家族成员主要有TOLL样受体(TLRs)、NOD样受体(NLRPs)、AIM2样受体(ALRs)、STING和RIG-I样受体(RLRs)等,其中部分TLRs、ALRs、STING和RLRs主要识别核酸(DNA或RNA)。一系列研究表明识别核酸的PRRs能通过不同的方式调控糖尿病及其并发症的发生发展,本文对此进行综述,研究结果提示调节识别核酸的PRRs及其信号通路能为糖尿病的预防、治疗、预后提供思路和理论基础。The incidence of diabetes is increasing all over the world,and the death rate from complications such as diabetic nephrotic syndrome and diabetic cardiomyopathy is also increasing.Pattern recognition receptor(PRRs)can activate innate immune response,eliminate related pathogens and maintain body homeostasis,which is closely related to the occurrence and development of diabetes.PRRs family members mainly include TOLL like receptors(TLRs),NOD like receptors(NLRPs),Aim2-like receptors(ALRs),STING and RIG-I like receptors(RLRs),among which TLRs,ALRs,STING and RLRs mainly recognize nucleic acids(DNA or RNA).A series of studies have shown that PRRs of nucleic acid identification can regulate the occurrence and development of diabetes and its complications in different ways.These findings suggest that the regulation of PRRs of nucleic acid identification and its signaling pathway can provide ideas and theoretical basis for the prevention,treatment and prognosis of diabetes.

关 键 词：模式识别受体 糖尿病 糖尿病性并发症 

分 类 号：R587.1[医药卫生—内分泌] R392.6[医药卫生—内科学]