小牛血清去蛋白注射液联合奥拉西坦治疗脑挫裂伤对患者GM-CSF、MPO水平的影响  

Effect of Deproteinized Calf Serum Injection Combined with Oxiracetam on Levels of GM-CSF and MPO in Patients with Brain Contusion and Laceration

作　　者：申海龙[1] 武艳娇 冯鹏超 李雅丽[4] 张龙[1] 陈云庆[1] SHEN Hai-long;WU Yan-jiao;FENG Peng-chao;LI Ya-li;ZHANG Long;CHEN Yun-qing(Department of Neurosurgery,The Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China;Department of Function,The Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China;Department of Acupuncture,The Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China;Ward 9,The Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China)

机构地区：[1]河北北方学院附属第二医院神经外科,河北张家口075100 [2]河北北方学院附属第二医院功能科,河北张家口075100 [3]河北北方学院附属第二医院针灸科,河北张家口075100 [4]河北北方学院附属第二医院九病区,河北张家口075100

出　　处：《河北北方学院学报（自然科学版）》2021年第4期11-14,19,共5页Journal of Hebei North University:Natural Science Edition

基　　金：张家口市重点研发计划项目(No.1931014D)。

摘　　要：目的探讨小牛血清去蛋白注射液联合奥拉西坦治疗脑挫裂伤对患者粒细胞-巨噬细胞集落刺激因子(GM-CSF)、髓过氧化物酶(MPO)水平的影响。方法136例脑挫裂伤患者采用随机数字表法分为对照组和研究组各68例,对照组应用奥拉西坦进行治疗,研究组在对照组治疗基础上加用小牛血清去蛋白注射液,连续治疗4周为1疗程。比较2组临床疗效、治疗前后血清细胞因子水平、神经功能相关评分及治疗期间不良反应情况。结果研究组总有效率95.59%,显著高于对照组的82.35%(P<0.05)。1疗程后,2组血清白细胞介素-6(IL-6)、GM-CSF、MPO水平较治疗前均降低,且研究组低于对照组(P<0.05)。1疗程后,2组简易智力状态检查量表(MMSE)、格拉斯哥评分表(GCS)评分较治疗前均升高,且研究组高于对照组(P<0.05);美国国立卫生研究院卒中量表(NIHSS)评分较治疗前降低,且研究组低于对照组(P<0.05)。治疗期间,研究组不良反应发生率7.35%,显著低于对照组的19.12%(P<0.05)。结论小牛血清去蛋白注射液联合奥拉西坦治疗脑挫裂伤能够明显降低患者血清GM-CSF、MPO水平,改善神经功能,并降低患者不良反应发生率,提高疗效。Objective To investigate the effect of calf serum deproteinized injection combined with oxiracetam on levels of macrophage colony-stimulating factor(GM-CSF)and myeloperoxidase(MPO)in patients with brain contusion and laceration.Methods A total of 136 patients with brain contusion and laceration were randomized into control group and study group by random number table method,68 cases in each group.The control group was treated with oxiracetam and the study group with calf serum deproteinized injection on the basis of the control group.Continuous treatment lasted four weeks as a course.The clinical efficacy after treatment,the serum cytokine levels and neurological function scores before and after treatment,and the incidence of adverse reactions during the treatment period were compared.Results The total effective rate of the study group was 95.59%,significantly higher than that of the control group(82.35%)(P<0.05).After one course of treatment,the levels of serum interleukin-6(IL-6),macrophage colony-stimulating factor(GM-CSF)and myeloperoxidase(MPO)were lower than those before treatment,and the study group was lower than the control group(P<0.05).After treatment,the scores of the Mini-mental state examination scale(MMSE)and the Glasgow score table(GCS)were higher than those before treatment,and the scores of the study group were higher than those of the control group;the score of National Institute of Health Stroke Scale(NIHSS)was lower than those before treatment and the control group(P<0.05).During the treatment period,the incidence of adverse reactions in the study group was 7.35%,significantly lower than that in the control group(19.12%)(P<0.05).Conclusion Calf serum deproteinized injection combined with oxiracetam in the treatment of brain contusion and laceration can significantly reduce the serum levels of GM-CSF and MPO,improve neurological function,reduce the incidence of adverse reactions and improve the efficacy.

关 键 词：小牛血清去蛋白注射液 奥拉西坦 细胞因子 神经功能 不良反应 

分 类 号：R651.15[医药卫生—外科学]