四川攀枝花地区健康成年体检人群外周血血小板及其相关参数生物参考区间的建立与评价  

Establishment and Evaluation of Peripheral Blood Platelets and Its Related Parameters in Healthy Adult Physical Examination Population in Panzhihua Region Sichuan Province

作　　者：李家明[1] 唐伍涛 李欣霏 杨德娟 邓明甜 胡昌玲 LI Jia-ming;TANG Wu-tao;LI Xin-fei;YANG De-juan;DENG Ming-tian;HU Chang-ling(Department of Clinical Laboratory,General Hospital of Panzhihua Iron and Steel Group,Sichuan Panzhihua 617000,China;Interns of General Hospital of Panzhihua Iron and Steel Group,Sichuan Panzhihua 617000,China;Medical Testing Centre of Great Maste,Chengdu 611731,China)

机构地区：[1]攀钢集团总医院检验科,四川攀枝花617000 [2]攀钢集团总医院,四川攀枝花617000 [3]大家医学检测中心,成都611731

出　　处：《现代检验医学杂志》2021年第2期122-125,共4页Journal of Modern Laboratory Medicine

摘　　要：目的探讨攀枝花地区健康成年体检人群血小板计数(PLT)、平均血小板体积(MPV)、血小板比容(PCT)、血小板体积分布宽度(PDW)和大型血小板比率(P-LCR)的生物参考区间,为临床诊疗提供更切合实际的依据。方法回顾性分析2018年4~10月健康体检的抗凝静脉全血样本9259例,用全自动血液分析仪检测,随机抽取符合要求的体检健康人群1026例,其中男性502例,女性524例,年龄在17~57岁间,按性别和年龄分组,以均数±标准差(x±s)表示健康体检人群的结果,男女两组间采用两大样本均数比较的u检验,年龄组间的两两比较采用q检验,P-LCR采用两样本率比较的χ^(2)检验,差异有统计学意义(P<0.05)。生物参考区间采用x±1.96s,与相关标准比较,并验证新建立的参考区间。结果攀枝花地区健康成人PLT生物参考区间男女有差异:男性(156~320)×10^(9)/L;女性(164~336)×10^(9)/L。而MPV,PCT,PDW-SD和P-LCR生物参考区间男女无差异:MPV 9.5~13.5fl,PC(0.18~0.36)×10^(9)/L,PDW-SD 9.2~19.8fl和P-LCR(21.3~48.7)%,但相同性别不同年龄组间P-LCR和PLT有差异,新建生物参考区间与相关标准有差异。结论不同地区人群血小板及相关参数的生物参考区间存在差异,建立适合攀枝花地区健康成年人群的生物参考区间有现实价值,非常必要。Objective To investigate the biological reference intervals of platelet count(PLT),mean platelet volume(MPV),platelet specific volume(PCT),platelet volume distribution width(PDW)and large platelet ratio(P-LCR)in healthy adult physical examination population in Panzhihua region,and provide more practical basis for clinical diagnosis and treatment.Methods Retrospective analysis of 9259 anticoagulant venous whole blood samples of health examination from April to October 2018,1026 healthy patients were randomly selected by automatic blood analyzer,of which 502 were male and 524 were female,aged 17~57 years,grouped by sex and age,and expressed results by mean(x±s).u test was used between two groups,and q test was used between two groups.P-LCR used theχ^(2) test compared with the two sample rates(P<0.05)and the difference was statistically significant.Bioreference interval adopted x±1.96s,compared with relevant standards and verify newly established reference intervals.Results The biological reference interval PLT healthy adults in Panzhihua Area was different between men and women:male(156~320)×10^(9)/L,female(164~336)×10^(9)/L.There was no difference between men and women in the MPV,PCT,PDW-SD and P-LCR biological reference intervals:MPV 9.5~13.5fl,PCT(0.18~0.36)×10^(9)/L,PDW-SD 9.2~19.8fl,P-LCR(21.3~48.7)%,but there were differences in P-LCR and PLT between different age groups of the same sex the reference interval differs from the relevant criteria.Conclusion There were differences in the biological reference interval of platelets and related parameters in different regions,so it is necessary to establish the biological reference interval suitable for healthy adult population in Panzhihua area.

关 键 词：生物参考区间 血小板 血小板体积分布宽度 健康成人 验证 

分 类 号：R446.111[医药卫生—诊断学]