遵义市新生儿先天性心脏病流行病学调查及危险因素分析  

Epidemiological investigation and risk factors analysis of neonatal congenital heart disease in Zunyi City

作　　者：于文兰 郑兴惠[2] YU Wenlan;ZHENG Xinghui(Graduate School of Zunyi Medical College,Zunyi,Guizhou 563003,China;Department of Neonatology,the First People's Hospital of Zunyi City,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医学院研究生院,贵州遵义563003 [2]贵州省遵义市第一人民医院新生儿科,563000

出　　处：《重庆医学》2021年第6期937-940,共4页Chongqing medicine

基　　金：贵州省卫健委科研项目(gzwkj2009-1-082)。

摘　　要：目的调查遵义市新生儿先天性心脏病(CHD)发生率,探讨其发生的危险因素。方法采用整群抽样,再利用单因素和多因素条件logistic回归分析方法对20个变量进行分析,筛选出与CHD发生相关的危险因素。结果从2484名新生儿中筛查出33例CHD患儿,其发生率为1.32%(33/2484),其中男13例,发生率为0.85%,女20例,发生率为2.10%。单因素分析初步筛选出6个可疑危险因素,再经多因素条件logistic回归分析结果显示,孕早期感冒(OR=2.09)、孕妇既往有不良生育史(OR=3.316)及父亲吸烟(OR=2.528)是新生儿CHD发生的相关危险因素。结论CHD的发生与孕妇暴露的环境因素有关,通过临床体检和心脏B超检查可将诊断提前到新生儿期。Objective To investigate the incidence of neonatal congenital heart disease(CHD)in Zunyi City and explore its risk factors.Methods Cluster sampling,and then single factor and multi-factor conditional logistic regression analysis method were used to analyze 20 variables,and screen out the risk factors related to CHD.Results Thirty-three children with CHD were screened out from 2484 newborns,the incidence of CHD was 1.32%,of which 13 were males with the incidence of 0.85%,and 20 were females with the incidence of 2.10%.Six suspected risk factors were initially screened out by single condition logistic regression analysis,and the results of multi-factor conditional logistic regression analysis showed that cold during the early stage of pregnancy(OR=2.09),gravid with abnormal child bearing history(OR=3.316)and smoking history of father(OR=2.528)were correlative risk factors of CHD.Conclusion The occurrence of CHD is related to the environmental factors exposed to pregnant women.The diagnosis can be advanced to the neonatal period through clinical physical examination and cardiac B-ultrasound.

关 键 词：心脏缺损 先天性 儿童 流行病学研究 危险因素 

分 类 号：R725.4[医药卫生—儿科]