外泌体在肥胖症中的研究进展  

Research progress of exosomes in obesity

作　　者：张月月 陈颖 李文娜 ZHANG Yue-yue;CHEN Ying;LI Wen-na(Department of Pharmacology,Zunyi Medical University Zhuhai Campus,Zhuhai GUANGDONG 519000,China)

机构地区：[1]遵义医科大学珠海校区药理学教研室,广东珠海519000

出　　处：《中国新药与临床杂志》2021年第3期178-182,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：国家自然科学基金(81760697);贵州省科学技术基金(黔科合基础[2017]1220);贵州省中药现代化科技产业研究开发专项(黔科合ZY字[2013]3018);珠海市优势学科建设计划(2015-2018)。

摘　　要：外泌体是细胞分泌的一种囊泡样小体,可通过受体与配体间的相互作用刺激靶细胞,或通过向靶细胞转移各种生物活性分子如膜受体、蛋白质、mRNA和miRNA等方式在细胞间通讯中扮演重要角色,其中研究最多的是miRNAs。最近研究表明,外泌体中特定的miRNAs通过调控脂肪的形成、经典棕色脂肪组织功能和白色脂肪组织褐变过程,以及参与脂肪组织巨噬细胞的活化状态,在肥胖症的病理过程中发挥关键作用。Exosomes are a kind of secreted nanoscale vesicles that play a key role in intercellular communication,which stimulates target cells through the interactions between receptors and ligands or by transferring various biologically active molecules,such as membrane receptors,proteins,mRNAs,miRNAs,and so on.Among them,miRNAs are the most studied.Recent studies have shown that specific miRNAs in exosomes play a key role in the pathological process of obesity by regulating the formation of fat,classic brown adipose tissue function and white adipose tissue browning,as well as the activation state of adipose tissue macrophages.

关 键 词：外泌体 肥胖症 脂肪组织 

分 类 号：R966[医药卫生—药理学] R969[医药卫生—药学]