儿科输液门诊中糖皮质激素的使用与安全性分析  

Analysis on Usage and Safety of Glucocorticoids in Pediatric Out-patient Transfusion Room

作　　者：颜颖慧 桂环[1] 黄艳[1] 王凤娇[1] YAN Ying-hui;GUI Huan;HUANG Yan;WANG Feng-jiao(Children's Hospital of Soochow University,Suzhou Jiangsu 215025,China)

机构地区：[1]苏州大学附属儿童医院,江苏苏州215025

出　　处：《抗感染药学》2021年第1期11-15,共5页Anti-infection Pharmacy

基　　金：国家自然科学基金青年科学基金项目(编号:81703478)。

摘　　要：目的:分析医院儿科输液门诊静脉用糖皮质激素(注射用甲泼尼龙琥珀酸钠、注射用氢化可的松琥珀酸钠)的使用状况与安全性,为临床儿童合理用药提供参考。方法:采用回顾性调查方法,抽取医院门诊30 d静脉用糖皮质激素输液处方18029张,分析其静脉用糖皮质激素药物使用的临床诊断、患者信息及治疗用药指征的相关性与用药的合理性。结果:抽取的30 d静脉用糖皮质激素处方18029张,占月均输液处方(32714张)的55.11%,其中80%以上处方为呼吸系统疾病用药;静脉用糖皮质激素的品种选择、剂量、给药途径基本符合治疗原则,但仍存在缺少循证证据支持应用激素治疗的情况,尤其是氢化可的松在上呼吸道疾病和感染性疾病中单纯以退热为目的的使用。结论:儿科门诊输液中静脉用糖皮质激素的使用仍不够规范,使用激素类药物退热的情况较为普遍,短期使用应警惕皮疹等不良反应的发生。Objective:To analyze the usage and safety of intravenous glucocorticoids(sodium methylprednisolone succinate for injection and sodium hydrocortisone succinate for injection)in the out-patient department of pediatric infusion in hospital,and to provide reference for rational drug use in children.Methods:By retrospective investigation,18029 intravenous glucocorticoids infusion prescriptions for 30 days were extracted from the out-patient department of a hospital to analyze the clinical diagnosis of intravenous glucocorticoid drug use,the correlation of patient information to indications and the rationality of drug use.Results:18,029 prescriptions of 30-day intravenous glucocorticoids were extracted,accounting for 55.11%of the total monthly infusion prescriptions(32,714),of which more than 80%were drugs for respiratory diseases.The variety selection,dose and route of intravenous glucocorticoids are basically consistent with the principles of treatment,but there is still a lack of evidence-based evidence to support the use of corticosteroids,especially the use of hydrocortisone solely for the purpose of antipyretic in upper respiratory diseases and infectious diseases.Conclusion:The usage of glucocorticoids for intravenous infusion in out-patient department of pediatrics is still not standardized.The use of hormone drugs to reduce fever is relatively common,and the occurrence of adverse drug reactions such as rash should be warned when using in the short period.

关 键 词：静脉用糖皮质激素 甲泼尼龙琥珀酸钠 氢化可的松琥珀酸 儿童用药 用药指征 

分 类 号：R969.3[医药卫生—药理学]