临床药师干预用药对老年脑梗死伴肺部感染患者临床抗感染治疗的影响  

Influence of Clinical Pharmacists'Intervention on ClinicalMedication of Senile Cerebral Infarction Patients with Pulmonary Infection

作　　者：魏艳芳 吴琪 刘梅娟 WEI Yan-fang;WU Qi;LIU Mei-juan(Department of Pharmacy,Rongjun Hospital of He'nan,Xinxiang He'nan 453000,China)

机构地区：[1]河南省荣军医院药剂科,河南新乡453000

出　　处：《抗感染药学》2021年第1期45-48,共4页Anti-infection Pharmacy

摘　　要：目的:考察临床药师干预用药对老年脑梗死伴肺部感染患者临床抗感染治疗的影响。方法:选取2018年1月—2019年1月间收治的老年脑梗死伴肺部感染患者46例临床资料为干预前组,另选取2019年2月—2020年1月间收治的老年脑梗死伴肺部感染患者46例临床资料为干预后组(由临床药师干预用药);分析干预前后脑梗死伴肺部感染患者的体温、白细胞(WBC)计数、中性粒细胞计数比例、降钙素原(PCT)、C反应蛋白(CRP)等感染指标的变化情况以及标本中病原菌的分布及其抗感染药物的使用情况。结果:92例患者病原菌感染以鲍曼不动杆菌为主(31.52%),其次为产气肠杆菌和大肠埃希菌(均为3.26%);干预后组患者临床感染指标(体温、WBC计数、中性粒细胞计数、CRP)测得值均低于干预前组(P<0.05),头孢哌酮-舒巴坦钠、依替米星、头孢他啶的用药频度(DDDs)分别为38.78、30.75和23.79;干预前组患者头孢哌酮-舒巴坦钠、哌拉西林-舒巴坦钠及依替米星的DDDs分别为37.63、17.45和13.68。结论:临床药师干预老年脑梗死伴肺部感染患者临床抗感染用药,有效降低了炎症指标,提高了抗感染药物用药的正确率和抗感染药物治疗方案的有效性。Objective:To investigate the influence of clinical pharmacists'intervention on the clinical anti-infective medication of senile cerebral infarction patients with pulmonary infection.Methods:The clinical data of 46 senile cerebral infarction patients with pulmonary infection admitted from January 2018 to January 2019 were selected as the preintervention group,and the clinical data of 46 senile cerebral infarction patients with pulmonary infection admitted from February 2019 to January 2020 were selected as the post-intervention group(with intervention medication by clinical pharmacists).The changes of clinical infection indexes(body temperature,WBC,neutrophils,CRP),the distribution of pathogenic bacteria and the medication of anti-infective drugs were analyzed in patients of cerebral infarction with pulmonary infection before and after intervention.Results:92 patients were mainly infected by Acinetobacter baumannii(31.52%),followed by Enterobacter aerogenes and Escherichia coli(3.26%).After intervention,the clinical infection indexes(body temperature,WBC,neutrophilic granulocyte count,CRP)of the patients in the group were all lower than those in the group before intervention(P<0.05).The drug frequency(DDDs)of cefoperazone-sulbactam,etimicin and ceftazidime were 38.78,30.75 and 23.79,respectively.The DDDs of cefoperazone-sulbactam,piperacillin-sulbactam and etimicin were 37.63,17.45 and 13.68,respectively,in the group before intervention.Conclusion:Clinical pharmacists participated in clinical anti-infective medication for elderly patients of cerebral infarction with pulmonary infection,which effectively decreased inflammation indicators and improved the accuracy of anti-infective medication and the effectiveness of anti-infective drug therapy.

关 键 词：老年脑梗死 肺部感染 临床药师干预 抗感染用药 

分 类 号：R969.3[医药卫生—药理学]