某胸科医院122例肺结核患者治疗期间口腔真菌感染的影响因素分析及其干预对策  

Analysis on Influencing Factors of Oral Fungal Infection During Treatment in 122 Patients with TB in a Chest Hospital and Its InterventionMeasures

作　　者：吕娅敏[1] 梁丽丽[1] LüYa-min;LIANG Li-li(Department of Tuberculosis,The Chest Hospital of He'nan,Zhengzhou 450003,China)

机构地区：[1]河南省胸科医院结核内科,郑州450003

出　　处：《抗感染药学》2021年第1期110-113,共4页Anti-infection Pharmacy

基　　金：中美合作结核病临床诊断与治疗新技术的研究项目(编号:2014DFA30340)。

摘　　要：目的:分析医院肺结核患者口腔真菌感染的影响因素与广谱抗菌药物使用的相关性及其干预对策。方法:抽取2017年5月—2019年5月间医院收治的肺结核患者122例临床资料,按其是否发生口腔真菌感染将其分为感染组(n=46)和非感染组(n=76);采用单因素和多因素Logistic分析相结合的方法,分析肺结核患者发生口腔真菌感染的危险因素以及与广谱抗菌药物使用的相关性及其干预对策。结果:肺结核患者发生口腔真菌感染与使用广谱抗菌药物、使用激素≥7 d以及伴有糖尿病史具有相关性,也是肺结核患者发生口腔真菌感染的主要危险因素;而患者营养状况良好、免疫功能正常是预防口腔真菌感染的保护因素。结论:临床应针对其口腔真菌感染的影响因素及时采取有效干预措施,以避免或减少患者抗结核药物治疗后口腔真菌感染的发生。Objective:To analyze the influencing factors of oral fungal infection during treatment in pulmonary tuberculosis(TB)patients in a hospital,and to explore its intervention countermeasures.Methods:The clinical data of 122 TB patients admitted to hospitals from May 2017 to May 2019 were extracted,and they were divided into infected group(n=46)and non-infected group(n=76)based on whether they had oral fungal infection.Univariate and multivariate Logistic analysis was used to analyze the risk factors of oral fungal infection during treatment in patients with TB,their correlation with the use of broad-spectrum antimicrobial agents and their intervention strategies.Results:The occurrence of oral fungal infection in TB patients was correlated with the use of broad-spectrum antibacterial drugs,the use of hormone≥7 d,and the history of diabetes,which was also the main risk factor for oral fungal infection in TB patients.Good nutritional status and normal immune function are the protective factors to prevent oral fungal infection.Conclusion:Clinically,effective intervention measures should be taken in time for the influencing factors of oral fungal infection,in order to avoid or reduce the incidence of oral fungal infection after anti-tuberculosis drug treatment.

关 键 词：肺结核 口腔真菌感染 影响因素 干预对策 

分 类 号：R197.323.4[医药卫生—卫生事业管理]