头孢呋辛钠眼内前房注射对白内障患者术后眼内炎的防治效果的临床分析  

Efficacy of Cefuroxime Sodium in Injecting EyeAnterior Chamber on Prevention and Treatment of Postoperative Endophthalmitis in Patients with Cataract

作　　者：周媛[1] 张文[1] 陈韵[1] ZHOU Yuan;ZHANG Wen;CHEN Yun(Ophthalmic Center,The Second Affiliated Hospital of Soochow University,Suzhou Jiangsu 235004,China)

机构地区：[1]苏州大学附属第二医院眼科中心,江苏苏州235004

出　　处：《抗感染药学》2021年第1期132-134,共3页Anti-infection Pharmacy

摘　　要：目的:分析头孢呋辛钠眼内前房注射对白内障患者术后眼内炎的防治效果。方法:选取2017年1月—2019年12月间门诊眼科诊疗行白内障超声乳化与人工晶体植入术的白内障患者2645例临床资料;其中,2017年1月—2018年12月间行白内障手术患者1575例为对照组(采用常规治疗);另取2019年1月—12月间行白内障手术患者1070例为观察组(采用前房注射头孢呋辛钠1 mg/0.1 mL治疗);比较两组患者术后4周眼内炎的感染情况。结果:对照组患者用药后术后4周内759例患者最佳矫正视力大于1.0,636例患者视力>0.5~0.9,而视力小于0.1患者仅为29例;而观察组患者用药后术后4周内579例患者最佳矫正视力大于1.0,392例患者视力>0.5~0.9,而视力小于0.1仅有9例;观察组患者术后4周内未见眼内炎的发生,而对照组患者术后发生眼内炎2例,两组间数据的比较其差异无统计学意义(P0.150>0.05);对照组发生的2例眼内炎患者经治疗后均治愈,而观察组患者头孢呋辛钠眼内前房注射给药后均未见角膜内皮失代偿、视网膜毒性等药物相关毒性和过敏反应。结论:头孢呋辛钠眼内前房注射有效预防了术后眼内感染,避免了术后眼内感染。Objective:To analyze the clinical efficacy of anterior chamber injection of cefuroxime sodium on prevention and treatment of postoperative endophthalmitis in patients with cataract.Methods:The clinical data of 2645 cataract patients undergoing phacoemulsification and intraocular lens implantation in outpatient ophthalmic diagnosis and treatment from January 2017 to December 2019 were selected.Among them,1575 patients underwent cataract surgery from January 2017 to December 2018 were in the control group(conventional treatment was used).In addition,1070 patients undergoing cataract surgery from January to December 2019 were selected as the observation group(cefuroxime sodium was injected into the anterior chamber at 1 mg/0.1 mL).The infection of endophthalmitis for 4 weeks after operation was compared between the two groups.Results:In the control group,759 patients had optimal corrected visual acuity greater than 1.0,787 patients had visual acuity between 0.5 and 0.9,and only 29 patients had visual acuity less than 0.1 within 4 weeks after the treatment.In the observation group,the best corrected visual acuity was greater than 1.0 in 579 patients,482 patients were between 0.5 and 0.9,and 9 patients with visual acuity less than 0.1 within 4 weeks after the treatment.No endophthalmitis was observed in patients in the observation group within 4 weeks after surgery,while 2 patients in the control group had endophthalmitis after surgery,and the difference between the two groups was not statistically significant(P0.150>0.05).The 2 patients with endophthalmitis in the control group were cured after treatment,while no drug-related toxicity and allergic reactions such as corneal endothelium decompensation,retinal toxicity and other drugs were observed after cefuroxime sodium was injected into the anterior chamber of the eye in the observation group.Conclusion:Cefuroxime sodium injection in the anterior chamber can effectively prevent postoperative intraocular infection and avoid postoperative intraocular infection.

关 键 词：白内障手术 前房注射 头孢呋辛 眼内炎 

分 类 号：R969.4[医药卫生—药理学]