因口腔健康状况就诊患者HIV感染现状及感染者WB带型分析  

Analysis of HIV infection status of patients with oral diseases and WB pattern of HIV positives patients

作　　者：顾宁[1,2] 袁苗[1] 赵玉萍[1] GU Ning;YUAN Miao;ZHAO Yuping(Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学口腔疾病研究江苏省重点实验室,江苏南京210029 [2]南京医科大学附属口腔医院检验科,江苏南京210029

出　　处：《口腔医学》2021年第3期247-251,共5页Stomatology

摘　　要：目的了解南京某口腔医院就诊患者的HIV感染现状及HIV感染者的蛋白印迹实验(WB)蛋白抗体的分布特征。方法采用描述流行病学分析对患者一般资料进行回顾性调查。样本率的比较用SPSS 23.0软件进行卡方分析。结果2008年8月—2019年6月进行HIV抗体筛查的患者共计47825例,其中确诊HIV感染者35例,以20~40岁年龄组为主要年龄构成比,男女性别比6∶1,南京地区患者占60%。人群HIV感染率0.59/10万。人群HIV抗体筛查阳性率0.73‰,男性显著高于女性,黏膜组显著高于非黏膜组。HIV感染者首诊检出率88.57%。同时进行其他检测的HIV感染者,白色念珠菌阳性率100%,白细胞降低率7%。WB蛋白抗体条带分析,gp160,gp120和gp41的检出率均为100%,p55检出率最低为43.75%。结论口腔专科医院医生需要了解艾滋病的各种临床表现,促进口腔医院就诊患者中的HIV感染者的早发现和早治疗。日常诊疗工作中需加强防护,防止HIV的医源性感染。Objective To investigate the status of HIV infection in patients admitted to the stomatological hospital and the distribution characteristics of western blotting assay(WB)antibody in HIV positive patients.Methods Descriptive epidemiological analysis was used to review the general data of patients.The sample rates were compared using SPSS 23.0 software for Chi-Square analysis.Results A total of 47825 patients underwent HIV antibody screening from August 2008 to June 2019,among whom 35 were confirmed to be infected with HIV.The age group of 20-40 years old was the main age composition,with the male-female sex ratio of 6∶1,and Nanjing natives accounted for 60%.The HIV infection rate in the population was 0.59 per 100000.The positive rate of HIV antibody screening in population was 0.73‰,among which the male was significantly higher than the female,and the mucosal group was significantly higher than the non-mucosal group.The proportion of HIV positive patients screened at the first visit was 88.57%.Among those infected with HIV who underwent other tests at the same time,the positive rate of candida albicans was 100%and the white blood cell decline rate was 7%.WB antibody band analysis showed that the detection rates of gp160,gp120 and gp41 were all 100%,and the detection rate of p55 was the lowest,43.75%.Conclusion Doctors in stomatological hospitals need to be familiar with various clinical manifestations of AIDS to promote the early detection and treatment of HIV infection patients.Protection should be strengthened during routine diagnosis and treatment to prevent the iatrogenic infection of HIV.

关 键 词：人类免疫缺陷病毒 带型分析 口腔 

分 类 号：R512.91[医药卫生—内科学]