褪黑素在牙周炎诊治中的研究进展  

Progress of research on melatonin in the diagnosis and treatment of periodontitis

作　　者：杨世缘 胡月 周宇宁 桂志鹏[1] 徐袁瑾[1] YANG Shiyuan;HU Yue;ZHOU Yuning;GUI Zhipeng;XU Yuanjin(Department of Oral Surgery,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔外科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011

出　　处：《口腔医学》2021年第3期259-264,共6页Stomatology

基　　金：国家自然科学基金面上项目(81771038)。

摘　　要：褪黑素是一种色氨酸衍生的激素,由大脑松果体分泌。近年来,大量研究发现褪黑素可以促进牙周组织健康,其在牙周炎中的作用受到越来越多的关注。该文就褪黑素在唾液中的浓度与牙周炎的相关性、褪黑素改善牙周状态的机制以及褪黑素作为外源性化学因子应用在牙周骨组织工程中的研究进展进行综述,以期为牙周炎的诊断和治疗提供新思路。Melatonin is a tryptophan-derived hormone secreted by the pineal gland of brain. In recent years, a large number of studies have found that melatonin can promote periodontal health, so its role in periodontitis has received more and more attention. This article reviews the correlation between melatonin concentration in saliva and periodontitis, the mechanisms of melatonin affecting periodontitis, and the progress in the application of melatonin as an exogenous chemical factor in periodontal bone tissue engineering, in order to provide new ideas for the diagnosis and treatment of periodontitis.

关 键 词：褪黑素 骨 牙周炎 组织工程 

分 类 号：R7I8.4[医药卫生—临床医学]