H型高血压患者MTHFR C677T基因多态性及其与血压、HCY水平的关系  

Polymorphism of MTHFR C677T gene and its relationship with blood pressure homocysteine levels in patients with H type hypertension

作　　者：韦宝敏[1] 潘兴寿[1] 李天资[1] 梁烨[1] 李近都 WEI Baomin;PAN Xingshou;LI Tianzi;LIANG Ye;LI Jindu(Affiliated Hospital of Youjiang National Medical University,Baise,Guangxi 533000,China;Affiliated Tumor Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]右江民族医学院附属医院心血管内科,广西百色533000 [2]广西医科大学附属肿瘤医院肝胆外科,广西南宁530012

出　　处：《检验医学与临床》2021年第7期889-892,共4页Laboratory Medicine and Clinic

基　　金：国家自然科学基金项目(81060028);广西壮族自治区百色市科学技术基金项目(20140923、20180038)。

摘　　要：目的探讨H型高血压患者亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点碱基的分布特征及其与血压、同型半胱氨酸(HCY)水平的关系。方法检测2019年1-8月该院收治的135例H型高血压患者(观察组)的收缩压、舒张压、HCY水平和MTHFR基因C677T位点碱基分布特征,并与134例非H型高血压者(对照组)比较。结果观察组MTHFR基因C677T位点TT纯合子突变频率较对照组高(P<0.01),T等位频率较对照组高(P<0.01)。TT纯合子突变型收缩压和HCY水平较CC型高(P<0.01)。观察组CC、CT和TT型HCY水平高于对照组(P<0.05);在观察组中,TT型HCY水平高于CC型(P<0.05),也高于CT型(P<0.05);在对照组中,TT型HCY水平高于CC型(P<0.05),TT型HCY水平与CT型比较,差异无统计学意义(P>0.05)。结论H型高血压患者MTHFR基因C677T位点TT纯合子突变频率高,MTHFR基因C677T位点碱基突变对收缩压和HCY水平有影响,MTHFR基因C677T碱基突变型携带者HCY和总胆固醇水平升高。Objective To investigate the distribution characteristics of methyltetrahydrofolic acid reductase(MTHFR)gene C677T site nucleotide base in patients with H hypertension and its correlation with blood pressure,homocysteine(HCY)levels.Methods From January to August 2019,135 patients with type H hypertension(observation group)in our hospital were compared with 134 patients with non-type H hypertension(control group)in their systolic pressure,diastolic pressure,HCY and MTHFR gene C677T site nucleotides.Results The MTHFR gene C677T site TT homozygous mutation frequency was significantly higher in the observation group than that in the control group(P<0.01),while T isometric frequency is significantly higher than that of the control group(P<0.01).The levels of systolic pressure and HCY in TT homozygous mutant were higher than those in CC type(P<0.01).The HCY levels of CC,CT and TT type in observation group were higher than those in control group(P<0.05).In the observation group,the level of HCY in TT type was higher than that in CC type and CT type(P<0.05).In the control group,the level of HCY in TT type was higher than that in CC type(P<0.05),and there was no statistical significance in the level of HCY in TT type compared with CT type(P>0.05).Conclusion The frequency of TT homozygous mutation at C677T site of MTHFR gene is high in patients with H type hypertension,and the base mutation at C677T site of MTHFR gene has influence on systolic pressure and HCY levels.Carriers of the C677T base mutation at MTHFR gene have elevated HCY and total cholesterol.

关 键 词：H型高血压 亚甲基四氢叶酸还原酶 基因突变 同型半胱氨酸 

分 类 号：R544.1[医药卫生—心血管疾病] R446.1[医药卫生—内科学]