基于中医综合治疗模式促进COPD缓解期病情改善及气道黏膜组织修复机制研究  

The mechanism of promoting the improvement of chronic obstructive pulmonary disease remission and the repair of airway mucosa tissue based on the comprehensive treatment model of Traditional Chinese Medicine

作　　者：张元雯[1] 宋长丽 危蕾 王振伟[1] ZHANG Yuanwen;SONG Changli;WEI Lei;WANG Zhenwei(Department of Respiration,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Traditional Chinese Medicine,Shanghai Jiangong Hospital,Shanghai 200083,China;Department of Respiration,Shanghai Baoshan Hospital of Integrated Chinese and Western Medicine,Shanghai 201999,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院呼吸科,上海200437 [2]上海建工医院中医科,上海200083 [3]上海市宝山区中西医结合医院呼吸科,上海201999

出　　处：《检验医学与临床》2021年第7期897-900,共4页Laboratory Medicine and Clinic

基　　金：上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-FWTX-6010];上海市卫生和计划生育委员会中医优势病种(肺胀病)培育项目(zybz-2017007);上海中医药大学预算内项目(18LK048);上海市进一步加快中医药事业发展三年行动计划治未病服务产品和技术项目[ZY(2018-2020)-ZWB-1001-CPJS19];上海市科学技术委员会科研计划项目(19401933200)。

摘　　要：目的研究中医综合治疗模式促进慢性阻塞性肺疾病(COPD)缓解期病情改善及气道黏膜组织修复机制。方法选取2017年10月至2019年9月该院COPD缓解期患者82例,采用随机数字表法分为观察组和对照组,各41例。对照组采用健康教育、家庭氧疗、肺康复训练及常规西药治疗,观察组采用中医综合治疗模式。观察和检测两组患者治疗后6个月内急性发作次数和治疗前后COPD评估测试量表(CAT)评分、肺通气功能[第1秒用力呼气容积(FEV 1)、用力肺活量(FVC)、FEV 1/FVC]、血清炎症细胞因子[白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]及血管内皮生长因子(VEGF)水平。结果观察组急性发作总发生率[4.88%(2/41)]低于对照组[19.51%(8/41)],差异有统计学意义(P<0.05)。治疗后,观察组CAT评分和血清IL-8、TNF-α及VEGF水平低于对照组,FEV 1/FVC高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者CAT评分、血清IL-8、TNF-α及VEGF水均较治疗前下降,FEV 1/FVC较治疗前升高,差异均有统计学意义(P<0.05)。结论中医综合治疗模式通过调节脏腑功能、纠正病理状态有利于抑制炎性反应、促进气道黏膜组织修复,疗效显著。Objective To study the comprehensive treatment mode of Traditional Chinese Medicine to promote the improvement of chronic obstructive pulmonary disease(COPD)and the repair mechanism of airway mucosa tissue.Methods Totally 82 patients with COPD in our hospital from October 2017 to September 2019 were selected and divided into observation group and control group according to random number table,41 cases in each group.The control group was given health education,home oxygen therapy,lung rehabilitation training and Conventional Western Medicine,and the observation group was given a comprehensive treatment model of Traditional Chinese Medicine.The number of acute attacks within 6 months after treatment and the COPD assessment test scale(CAT),pulmonary ventilation function[1 second forced expiratory volume(FEV 1),forced vital capacity(FVC),FEV 1/FVC],serum inflammatory cytokines[interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],and vascular endothelial growth factor(VEGF)levels were observed and compared within 3 months after treatment.Results The total incidence of acute attack in the observation group[4.88%(2/41)]was lower than that in the control group[19.51%(8/41)],and the difference was statistically significant(P<0.05).After treatment,the CAT score,serum IL-8,TNF-αand VEGF in the observation group were lower than those in the control group,and FEV 1/FVC were higher than the control group,the difference was statistically significant(P<0.05).After treatment,compared with before treatment,CAT score,serum IL-8,TNF-αand VEGF level decreased,FEV 1/FVC level increased,the difference was statistically significant(P<0.05).Conclusion The comprehensive treatment mode of Traditional Chinese Medicine can inhibit the inflammatory reaction and promote the repair of airway mucosa by regulating the function of viscera and correcting the pathological state.

关 键 词：慢性阻塞性肺疾病 缓解期 中医综合治疗模式 气道损伤 黏膜修复 

分 类 号：R563.9[医药卫生—呼吸系统]