武汉地区新型冠状病毒轻、重症感染检验结果危险因素分析  

Analysis of laboratory results of mild and severe infection risk factors in COVID-19 in Wuhan

作　　者：陶然[1,2] 程雅婷 何君[1,2,3] 莫南勋 李慧源[4,5] 陈丹 邓小燕 李妙知 肖含 谢文 张玲 TAO Ran;CHENG Yating;HE Jun;MO Nanxun;LI Huiyuan;CHEN Dan;DENG Xiaoyan;LI Miaozhi;XIAO Han;XIE Wen;ZHANG Ling(Guangzhou KingMed Center for Clinical Laboratory,Guangzhou,Guangdong 510005,China;Guangzhou Medical University,Guangzhou,Guangdong 510006,China;Research Certer for Clinical Virology of National Clinical Research Center for Respiratory Disease,Guangzhou,Guangdong 510005,China;Wuhan Kingmed Center for Clinical Laboratory,Wuhan,Hubei 430100,China;Research Certer for Clinical Virology of National Clinical Research Center for Respiratory Disease,Wuhan,Hubei 430100,China;Wuhan Leishenshan Hospital,Wuhan,Hubei 430200,China;Jilin Kingmed Center for Clinical Laboratory,Changchun,Jilin 130000,China;Zhongnan Hospital of Wuhan University,Wuhan,Hubei 430071,China)

机构地区：[1]广州金域医学检验中心,广东广州510005 [2]广州医科大学金域检验学院,广东广州510006 [3]国家呼吸系统疾病临床医学研究中心病毒诊断研究中心,广东广州510005 [4]武汉金域医学检验所,湖北武汉430100 [5]国家呼吸系统疾病临床医学研究中心病毒诊断研究分中心,湖北武汉430100 [6]武汉雷神山医院,湖北武汉430200 [7]吉林金域医学检验所有限公司,吉林长春130000 [8]武汉大学中南医院,湖北武汉430071

出　　处：《检验医学与临床》2021年第7期956-959,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨武汉地区新型冠状病毒重症感染的危险因素。方法收集武汉雷神山医院就诊的新型冠状病毒肺炎(COVID-19)轻症(轻症组,42例)、重症(重症组,35例)感染者的27项检验结果,对两组资料进行χ2检验、秩和检验及非条件Logistic回归分析。结果其中17项检验指标在轻症组和重症组的差异有统计学意义(P<0.05),低密度脂蛋白(LDL)、天门冬氨酸氨基转移酶(AST)、钾离子(K^(+))、B型尿钠肽(BNP)为重症的独立危险因素,受试者工作特征(ROC)曲线分析结果显示,LDL、AST、K^(+)、BNP 4项指标的联合诊断具有最高的灵敏度,AST、K^(+)、BNP及LDL、AST、K^(+)检测组合具有最高的特异度。结论LDL、AST、K、BNP为重症的独立危险因素,监测重症患者的心功能和LDL对预防患者死亡至关重要。Objective To explore the risk factors of SARS-CoV-2 severe infection in Wuhan.Methods Twenty-seven test results of 42 mild and 35 severe COVID-19 patients were collected from Wuhan Leishenshan Hospital.The data of two groups were analyzed by chi square,rank sum test and unconditional Logistic regression analysis.Results The difference of 17 test results between mild group and severe group was statistically significant.LDL,AST,K^(+)and BNP were independent risk factors of severe COVID-19,the combined diagnostic ROC curve of the four indicators had the highest sensitivity and specificity.Conclusion LDL,AST,K^(+)and BNP are independent risk factors of severe COVID-19.It is very important to monitor the cardiac function and LDL of COVID-19 patients to prevent death.

关 键 词：新型冠状病毒 新型冠状病毒肺炎 轻症 重症 危险因素 

分 类 号：R446.5[医药卫生—诊断学]