中药动脉灌注治疗非创伤性股骨头坏死患者近期疗效观察  

Arterial perfusion of Chinese herbal medicines for non-traumatic osteonecrosis of the femoral head:observation of its short-term effect

作　　者：王荣田 李[2] 李泰贤 薛志鹏 刘道兵 何海军[2] 陈卫衡[1] WANG Rongtian;LI Yan;LI Taixian;XUE Zhipeng;LIU Daobing;HE Haijun;CHEN Weiheng(Department of Minimally-Invasive Joint Surgery,Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学第三附属医院微创关节科,100029 [2]中国中医科学院望京医院关节三科

出　　处：《介入放射学杂志》2021年第2期158-163,共6页Journal of Interventional Radiology

基　　金：国家自然科学基金面上项目(81973888、81473695);“十一五”国家科技支撑计划资助项目(2007AI20B035);中国中医科学院特色诊疗技术与方法研究项目(ZZ070864)。

摘　　要：目的观察中药注射剂动脉灌注治疗非创伤性股骨头坏死的近期临床疗效,为该病治疗提供一种可行有效的方法。方法采用前瞻性对照研究方法,将住院治疗的80例非创伤性股骨头坏死患者随机分为对照组(39例)和试验组(41例),分别予以西药、中药动脉灌注治疗。比较两组灌注术中股骨头供血动脉计数,术后7 d、90 d疼痛视觉模拟评分(VAS)、髋关节活动和术后90 d Harris髋关节功能评分。结果两组患者基线资料差异无统计学意义(P>0.05)。两组患者动脉灌注术后股骨头第1、第2、第3线血管计数均显著多于灌注前(P<0.001);灌注后7 d VAS评分均显著低于灌注前(P<0.001),髋关节活动度均显著高于灌注前(P<0.001),灌注后90 d VAS评分均显著低于灌注前(P<0.001),髋关节活动度(P<0.001)、Harris评分(P<0.001)均显著高于灌注前。试验组和对照组间灌注术后第1、第2、第3线股骨头供血血管计数比较,差异均无统计学意义(P>0.05);灌注后7、90 d VAS评分、髋关节活动度差异均无统计学意义(P>0.05),灌注后90 d Harris评分差异无统计学意义(P>0.05)。结论中药和西药动脉灌注治疗非创伤性股骨头坏死临床效果相当。中药动脉灌注治疗可快速改善股骨头局部血液循环,在短期内缓解关节疼痛症状,改善关节功能,值得临床推广应用。Objective To discuss the clinical short-term efficacy of arterial perfusion of Chinese herbal medicines in treating non-traumatic osteonecrosis of the femoral head(NONFH), and to provide a feasible and effective treatment for NONFH. Methods In this prospective control study, a total of 80 admitted patients with NONFH were randomly divided into control group(n=39, receiving arterial perfusion of Western drugs) and study group(n=41, receiving arterial perfusion of Chinese herbal medicines). The number of intraoperative blood supply arteries, postoperative 7 d and 90 d visual analogue scale(VAS) scores, the range of motion(ROM) of hip joints and postoperative 90 d Harris hip function score were compared between the two groups. Results There were no statistically significant differences in the baseline data between the two groups(P >0.05). In both groups, the postoperative number of blood supply arteries, including first, second and third line vessels feeding femoral head, were remarkably more than preoperative one(P<0.001);7 days after arterial perfusion,VAS scores were significantly lower than preoperative ones(P<0.001), and ROM of hip joints was significantly better than preoperative level(P<0.001);90 days after arterial perfusion, the VAS scores were lower than preoperative ones(P<0.001), while ROM of hip joints(P<0.001) and Harris hip function scores(P<0.001)were obviously higher than preoperative values. Between the two groups, there were no statistically significant differences in the number of blood supply arteries, including first, second and third line vessels feeding femoral head(P>0.05), in the postoperative 7 d, 90 d VAS scores and ROM of hip joints(P>0.05), and in the postoperative 90 d Harris hip function score(P>0.05). Conclusion In treating NONFH, arterial perfusion with Chinese herbal medicines and arterial perfusion with Western drugs have the same therapeutic effect.Arterial perfusion with Chinese herbal medicines can rapidly improve local blood circulation in femoral head,relieve joint pain sympt

关 键 词：非创伤性股骨头坏死 介入治疗 中药动脉灌注 近期疗效 

分 类 号：R681.8[医药卫生—骨科学]