麻杏石甘汤合玉屏风散对支原体肺炎患儿血清炎症因子、氧化应激及T淋巴细胞亚群的影响  

Effects of Maxing Shigan Decoction and Yupingfeng Powder on Serum Inflammatory Factor, Oxidative Stress and T Lymphocyte Subsets in Children with Mycoplasma Pneumonia

作　　者：狄雯雯[1] 李巧香[1] 陆影[1] 龙海旭 詹红艳[1] DI Wen-wen;LI Qiao-xiang;LU Ying;LONG Hai-xu;ZHAN Hong-yan(Department of Pediatrics,The Second Affiliated Hospital of Hunan University of traditional Chinese Medicine,Changsha,Hunan,410005,China)

机构地区：[1]湖南中医药大学第二附属医院儿科,湖南长沙410005

出　　处：《现代生物医学进展》2021年第2期320-324,共5页Progress in Modern Biomedicine

基　　金：湖南省中医药科研计划项目(201789)。

摘　　要：目的:探讨麻杏石甘汤合玉屏风散对支原体肺炎患儿血清炎症因子、氧化应激及T淋巴细胞亚群的影响。方法:选取我院儿科门诊于2016年12月至2018年7月间收治的86例支原体肺炎患儿,按随机数字表法分为观察组(43例)和对照组(43例)。对照组采用常规治疗,观察组在对照组基础上联合使用麻杏石甘汤合玉屏风散治疗,两组均治疗14 d。比较两组患儿疗效及临床症状变化情况,检测并比较两组患儿血清炎症因子、氧化应激指标和T淋巴细胞亚群变化情况,观察两组患儿治疗过程中的不良反应发生情况。结果:观察组总有效率为93.02%(40/43),高于对照组的76.74%(33/43)(P<0.05)。观察组患儿体温恢复时间、啰音消失时间、咳嗽消失时间和X线检查恢复正常时间均明显短于对照组(P<0.05)。治疗14 d后,两组患儿血清白介素-2(IL-2)水平明显升高,而白介素-4(IL-4)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平明显降低(P<0.05);且与对照组比较,观察组患儿治疗14 d后的血清IL-2水平明显较高,而IL-4、IL-6和TNF-α水平明显较低(P<0.05)。与治疗前比较,治疗5 d后、治疗14 d后,两组患儿血浆丙二醛(MDA)降低,超氧化物歧化酶(SOD)水平升高(P<0.05);与对照组比较,观察组治疗5 d后的血浆MDA明显较低,而SOD水平明显较高(P<0.05)。治疗14 d后,两组患儿CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)明显升高,且观察组高于对照组,而两组患儿CD8^(+)明显降低,且观察组低于对照组(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论:麻杏石甘汤合玉屏风散治疗支原体肺炎疗效显著,能够缓解临床症状、炎症反应,减轻患儿氧化应激状态,并可提高患儿免疫功能。Objective: To investigate the effects of Maxing Shigan Decoction and Yupingfeng Powder on serum inflammatory factors,oxidative stress and T lymphocyte subsets in children with mycoplasma pneumonia. Methods: 86 children with mycoplasma pneumonia who were admitted to pediatric clinicfrom in our hospital from December 2016 to July 2018 were selected.All the children were randomly divided into observation group(43 cases) and control group(43 cases) according to random number table method. The control group was treated with routine treatment, while the observation group was treated with Maxing Shigan Decoction and Yupingfeng Powder on the basis of the control group. Both groups were treated for 14 days. The curative effect and clinical symptoms of the two groups were compared. The changes of serum inflammatory factors, oxidative stress index and T lymphocyte subsets were detected and compared between the two groups. The occurrence of adverse reactions during the treatment of two groups of children were observed. Results:The total effective rate of the observation group was 93.02%(40/43), which was significantly higher than that of the control group76.74%(33/43)(P<0.05). The recovery time of body temperature, rale disappearance time, cough disappearance time and X-ray examination in the observation group were significantly shorter than those in the control group(P<0.05). After 14 days of treatment, the level of serum interleukin-2(IL-2) increased significantly in both groups. The levels of interleukin-4(IL-4), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) decreased significantly(P<0.05). Compared with the control group, the level of serum IL-2 in the observation group was significantly higher after 14 days of treatment, while the levels of IL-4, IL-6 and TNF-α were significantly lower(P<0.05).Compared with before treatment, after 5 days of treatment and 14 days of treatment, the plasma malondialdehyde(MDA) decreased, and superoxide dismutase(SOD) increased in both groups(P<0.05). Compared with the control g

关 键 词：麻杏石甘汤 玉屏风散 支原体肺炎 炎症因子 氧化应激 T淋巴细胞亚群 

分 类 号：R563.15[医药卫生—呼吸系统] R242[医药卫生—内科学]