微波促进合成苝单酰亚胺类化合物  

Microwave-Assisted Synthesis of Perylene Monoimide Derivatives

作　　者：王雅楠 王冲 祁禹鸣 李国凯 李小六[1] 王克让[1] Wang Ya'nan;Wang Chong;Qi Yuming;Li Guokai;Li Xiaoliu;Wang Kerang(Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry and Environmental ScienceHebei University,Baoding,Hebei 071002)

机构地区：[1]河北大学化学与环境科学学院药物化学与分子诊断教育部重点实验室河北省化学生物学重点实验室,河北保定071002

出　　处：《有机化学》2021年第2期702-707,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21572044,21778013);河北省科技厅(No.19241303D)资助项目.

摘　　要：以3,4;9,10-苝四甲酸酐为原料,经微波促进反应探讨了反应底物用量、反应时间和反应温度等条件对反应收率的影响,合成了系列苝单酰亚胺类化合物,其中2,6-二异丙基苯胺修饰的苝单酰亚胺化合物N-2’,6’-二异丙基苯胺基-3,4-苝单酰亚胺(PMI-1)在30min的反应时间内,分离收率可达64.1%.A fast and efficient method for the synthesis of aromatic amine modified perylene monoimide derivatives based on microwave-assisted reaction was developed.It is found that the amount of 2,6-diisopropylaniline showed very important influences on the synthetic yield.N-2',6'-Diisopropylanilino-3,4-perylene monoimide(PMI-1)was obtained with the isolated yield of 64.1%under the optimized condition of 7 equiv.of 2,6-diisopropylaniline at 170℃ and 80 W for 30 min.

关 键 词：苝单酰亚胺 微波促进合成 苝四甲酸酐 有机胺 

分 类 号：O625.6[理学—有机化学]