乙酸酐促进的[3+3]环化反应合成2-喹啉酮衍生物  

Synthesis of 2-Quinolinone Derivatives via[3+3]Cyclization Promoted by Acetic Anhydride

作　　者：赵瑜 陈卓 陈雪冰[1] Zhao Yu;Chen Zhuo;Chen Xuebing(School of Science,Honghe University,Mengzi,Yunnan 661199)

机构地区：[1]红河学院理学院,云南蒙自661199

出　　处：《有机化学》2021年第2期731-737,共7页Chinese Journal of Organic Chemistry

基　　金：云南省科技厅项目(NO.2017FD156);云南省高校科技创新团队资助项目.

摘　　要：2-喹啉酮结构单元广泛存在于天然产物和药物活性分子中,并且是重要的杂环合成砌块.建立了一种乙酸酐促进下,环状β-烯胺酮和丙二酸通过[3+3]环合反应构建2-喹啉酮化合物的新方法,产率为70%~87%.该方法具有原料简单易得、操作简便、路线简洁、目标化合物可修饰性强等优点.2-Quinolinone unit is frequently found in both natural products and pharmaceuticals.Furthermore,they are important heterocycle building blocks.Herein,a novel approach to the synthesis of 2-quinolinone derivatives has been established from[3+3]cyclization of β-enaminones with malonic acid promoted by acetic anhydride with yields of 70%~87%.The reaction is particularly attractive due to following advantages:simple starting materials,operational simplicity,concise synthetic route,easy purification,highly modifiability of target molecules and so on.

关 键 词：β-烯胺酮 2-喹啉酮:[3+3]环合 乙酸酐促进 

分 类 号：O626.323[理学—有机化学]