鼠神经生长因子不同给药方式治疗职业性噪声聋的临床研究  

Clinical study of different administration methods of mouse nerve growth factor in the treatment of occupational noise-induced deafness

作　　者：苏宁 杨丽辉[1] Su Ning;Yang Lihui(Department of Ear,Nose and Throat,the People′s Hospital of Liaoning Province,Shenyang 110000,China)

机构地区：[1]辽宁省人民医院耳鼻咽喉科,沈阳110000

出　　处：《中国医师进修杂志》2021年第3期220-224,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨鼓室内注射与肌肉注射鼠神经生长因子治疗职业性噪声聋(ONID)的疗效对比。方法选择辽宁省人民医院2018年1月至2019年12月收治的66例ONID患者为研究对象,按随机数字表法分为对照组、研究组,每组33例,两组患者均给予常规治疗,研究组在常规治疗基础上给予鼓室内注射鼠神经生长因子20μg,两耳分别隔日注射1次;对照组在常规治疗基础上给予肌肉注射鼠神经生长因子20μg,每日1次。两组均治疗28 d,比较两组左、右耳语频平均听阈,患者自觉耳鸣、头晕、头痛、失眠等症状改善情况,疗效,汉密尔顿抑郁量表(HAMD)评分及不良反应。结果两组治疗前左、右耳语频听阈比较差异无统计学意义(P>0.05)。治疗后研究组左、右耳语频听阈均明显低于对照组[(23.8±4.2)dB/HL比(34.5±3.9)dB/HL、(23.2±4.4)dB/HL比(35.9±5.1)dB/HL],差异有统计学意义(P<0.05)。研究组治疗后耳鸣、头晕症状改善率均明显高于对照组[93.3%(28/30)比72.4%(21/29)、15/17比8/16],差异有统计学意义(χ^(2)=4.584、5.705,P<0.05)。两组患者头痛、失眠症状改善率比较差异无统计学意义(P>0.05)。治疗后研究组总有效率明显高于对照组[90.9%(30/33)比69.7%(23/33)],差异有统计学意义(χ^(2)=4.694,P<0.05)。治疗后两组HAMD评分均降低,并且研究组HAMD评分低于对照组[(8.46±3.13)分比(10.55±3.83)分],差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论鼓室内注射鼠神经生长因子治疗ONID,能有效改善患者听力水平,减轻耳鸣、头晕症状,改善不良情绪,未见明显的不良反应。Objective To compare the therapeutic effect of drum room injection and intramuscular injection of rat nerve growth factor on occupational noise-induced deafness(ONID).Methods Sixty-six patients with ONID treatment from January 2018 to December 2019 in the People′s Hospital of Liaoning Province were divided into control group and study group by random number table,with 33 patients in each group.On the basis of conventional treatment,all patients in the study group were injected with 20μg rat nerve growth factor in the drum room,and each ear was injected once every other day.The control group was given intramuscular injection of rat nerve growth factor 20μg per day,and the patients in two groups were treatment for 28 d.The hearing threshold of left and right whisper frequency of the two groups were compared.The improvement of tinnitus,dizziness,headache,insomnia,other symptoms and the scores of Hamilton Depression Scale(HAMD)was compared between the two groups.Results Before treatment,the hearing thresholds of left whisper frequency and right whisper frequency in two groups had no significant differences(P>0.05).After treatment,the hearing thresholds of left whisper frequency and right whisper frequency in the study group were significantly lower than those in the control group:(23.8±4.2)dB/HL vs.(34.5±3.9)dB/HL,(23.2±4.4)dB/HL vs.(35.9±5.1)dB/HL,and there were statistical differences(P<0.05).After treatment,tinnitus and dizziness symptom improvement rate in the study group were higher than those in the control group:93.3%(28/30)vs.72.4%(21/29),15/17 vs.8/16,and there were statistically significant differences(χ^(2)=4.584 and 5.705,P<0.05).There was no statistically significant difference in the improvement rate of headache and insomnia symptoms between 2 groups(P>0.05).The total effective rate in the treatment group was significantly higher than that in the control group:90.9%(30/33)vs.69.7%(23/33),and there was statistical difference(χ^(2)=4.694,P<0.05).After treatment,the scores of HAMD of 2 groups wer

关 键 词：听觉丧失 噪声性 中耳 鼠神经生长因子 耳鸣 

分 类 号：R135.8[医药卫生—劳动卫生]