具有特定官能团化合物的手性传感研究进展  

Progress in Chiral Sensing of Chiral Compounds with Special Functional Groups

作　　者：张军瑶 李莉[1] ZHANG Jun-yao;LI Li(Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《化学试剂》2021年第2期152-162,共11页Chemical Reagents

基　　金：重大新药创制基金项目(2018ZX09711-001-005);中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-009)。

摘　　要：手性化合物在生命活动中起着重要作用,在医药学领域备受关注,建立快速高效的手性分析方法刻不容缓。手性传感方法具有专属性强、灵敏性高、操作简便、样品用量少等优点,能够快速确定对映体的绝对构型及对映体过量值。氨基、羟基和羧基是手性化合物中常出现的基团,也是手性传感器研究的重要对象。聚焦于纳米粒、量子点类手性传感材料和可用于手性传感的小分子化合物,综述了手性传感器在不同类型小分子的手性识别中的应用,并对手性传感器的发展进行了展望。Chiral compounds take an important role in life activities and have attracted much attention in the field of medicine.It is urgent to establish a fast and efficient chiral analysis method.The chiral sensing method has the advantages of high specificity,high sensitivity,easy operation and less sample consumption,which can quickly determine the absolute configuration and enantiomeric excess of enantiomers.Amino,hydroxyl and carboxyl groups are commonly found in chiral molecules,which are important objects of chiral sensor research.The applications of chiral sensors in recognition of different substrates are reviewed by focusing on nanoparticles,quantum dots and compounds for chiral sensing,and the development of chiral sensors is also discussed.

关 键 词：手性传感器 手性识别 绝对构型 对映体过量 纳米粒 量子点 化学 

分 类 号：O657.3[理学—分析化学]