细菌蛋白质磷酸化修饰研究进展  

Research progress in bacterial protein phosphorylation

作　　者：于静晨 张文婷 姚玉峰[1] Jingchen Yu;Wenting Zhang;Yufeng Yao(School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院,上海200025

出　　处：《微生物学报》2021年第2期357-367,共11页Acta Microbiologica Sinica

基　　金：国家自然科学基金(81772140)。

摘　　要：细菌蛋白质磷酸化修饰是调控细菌基因表达的一种重要方式,在细菌诸多生命活动中发挥非常关键的作用。本文系统概括了近年来细菌蛋白质磷酸化修饰的种类、双组分调控系统中磷酸化修饰调控信号传导、酪氨酸残基磷酸化修饰以及丝/苏氨酸残基磷酸化修饰等,同时对不同种类细菌蛋白质磷酸化修饰的功能进行综述,这些研究将对人类了解细菌蛋白质翻译后修饰的磷酸化调控及其与控制细菌感染的关系提供参考价值。As a key post-translational modification involved in regulation of gene expression, protein phosphorylation plays critical roles in bacterial physiological processes. Here we summarize the types of phosphorylation modification in bacteria, two-component signal transduction, tyrosine phosphorylation as well as serine/threonine phosphorylation, and discuss the regulatory mechanisms and functions of phosphorylation modifications in bacterial cellular processes in recent years. This review is helpful to understand the phosphorylation regulation of bacterial post-translational modifications and its relationship with the control of bacterial infections in the future.

关 键 词：细菌磷酸化 双组分调控系统 信号传导 激酶 磷酸酶 

分 类 号：Q936[生物学—微生物学]