基于中西医临床病症特点的糖尿病下肢血管病变动物模型分析  

Animal model analysis of diabetic lower extremity arterial disease based on clinical symptoms of traditional Chinese and Western medicine

作　　者：姜权 李艳[1] 宋亚刚 苗艳艳[1] 苗明三[1] JIANG Quan;LI Yan;SONG Ya-gang;MIAO Yan-yan;MIAO Ming-san(Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《中国中药杂志》2021年第4期772-776,共5页China Journal of Chinese Materia Medica

基　　金：国家国际合作基地项目(2016-65);河南省杰出外籍科学家工作室项目(GZS2019006);中原学者项目(162101510003)。

摘　　要：根据中西医对糖尿病下肢血管病变(lower extremity arterial disease,LEAD)病因病机的认识以及对患者的临床诊断标准和病症特点,建立LEAD动物模型评价标准,分析现有LEAD动物模型与中西医临床病症特点的吻合度,比较现有模型的优势及缺点,对不同模型的适用范围进行思考,提出现有模型可能的改进方法,为LEAD动物模型的改善提供助力。在模型完善与发展过程中,应更多体现中医证候特点,使LEAD动物模型更加贴近中西医临床特征。The evaluation standard of LEAD animal model was established according to the understanding of the etiology and pathogenesis of diabetic lower extremity vascular disease based on Chinese and Western medicine. The consistency between the existing LEAD animal model and the clinical characteristics of traditional Chinese and Western medicine was analyzed and evaluated. The advantages and disadvantages of the existing model were compared,the application scope of different models was considered,and the possible improvement methods of the existing model were proposed,so as to provide impetus for the improvement of LEAD animal model.We should reflect more characteristics of traditional Chinese medicine syndromes in the process of model improvement and development,making the LEAD animal model to get closer to clinical features of traditional Chinese and Western medicine.

关 键 词：糖尿病 下肢血管病变 中医证候 动物模型 

分 类 号：R587.2[医药卫生—内分泌] R543[医药卫生—内科学] R-332[医药卫生—临床医学]