深度烧伤创面削痂后植皮结合自体细胞再生技术治疗的临床研究  

Skin grafting aided with autologous cell regeneration technique in managment of deep burn wounds following tangential excision:a clinical study

作　　者：胡志成[1] 张逸[2] 唐冰[1] 王鹏[1] 黄韶斌 董云先 徐海琳 温日妮 荣燕超 朱家源[1] Hu Zhicheng;Zhang Yi;Tang Bing;Wang Peng;Huang Shaobin;Dong Yunxian;Xu Hailin;Wen Rini;Rong Yanchao;Zhu Jiayuan(Department of Burn Surgery,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Burns and Plastic Surgery,Nantong University Hospital,Nantong 226001,Jiangsu,China)

机构地区：[1]中山大学附属第一医院烧伤外科,广东广州510080 [2]南通大学附属医院烧伤整形科,江苏南通226001

出　　处：《中华生物医学工程杂志》2020年第6期536-540,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金面上资助项目(82072180,82072181,81871565);广东省科技科技发展专项资金(2016B090916001);广东省基础与应用基础研究基金(2019A1515012208);中山大学临床医学研究5010计划项目(2013001,2018002,2018003);高校基本科研业务费(19ykpy66)。

摘　　要：目的观察自体细胞再生技术治疗深度烧伤削痂后植皮的效果。方法分析2014年3月至2018年3月我科住院的深度烧伤患者54例,其中27例患者术中应用自体细胞再生技术(细胞分选仪,广州市麦施缔医疗科技有限公司,粤穗械备:20201238号)结合游离皮片移植,27例患者常规使用游离皮片移植修复创面。于术后对比两组创面的愈合时间和愈合效果。结果应用自体细胞再生技术结合植皮后,与对照组相比,实验组愈合时间更短愈合后远期效果更佳,两组差异有统计学意义(P<0.05)。在术后首次换药时疼痛程度,术后植皮并发症方面,两组之间差异无统计学意义。结论自体细胞再生技术可有效促进烧伤创面愈合,缩短愈合时间,并且安全性高。Objective To investigate the outcomes of skin grafting aided with autologous cell regeneration technique for treatment of deep burn wounds following tangential excision of eschars.Methods Included in this study were a total of 54 patients with deep burns hospitalized in our department between March 2014 and March 2018.Among them,27 patients(study group)underwent free skin grafting aided with autologous cell regeneration technique(MYSEED■kit),and the other 27(control group)received conventional free skin grafting,for wound repair.The wound healing time and healing outcome after operation were compared between the two groups.Results Compared with the control group,use of autologous cell regeneration technique lead to shorter healing time and better long-term outcome after wound healing in the study group,with statistically significant difference between groups(P<0.05).The two groups did not differ statistically in terms of pain during the first dressing change and postoperative complications of the skin grafting.Conclusion Use of autologous cell regeneration technique can effectively promote healing of burn wounds and shorten the healing time,with high patient safety profiles.

关 键 词：深度烧伤 临床研究 皮片移植 

分 类 号：R644[医药卫生—外科学]