黄连素和生活方式干预治疗糖尿病前期患者的疗效及预后  

Clinical study of berberine and lifestyle intervention in the treatment of prediabetes

作　　者：王利[1] 葛辉[1] 卫国红[1] 彭龙云[1] 吴利秋 叶惠娟[1] 刘烈华[1] WANG Li;GE Hui;WEI Guo-Hong(The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,Guangdong,China)

机构地区：[1]中山大学附属第一医院,广东广州510080

出　　处：《中国老年学杂志》2021年第8期1595-1598,共4页Chinese Journal of Gerontology

基　　金：国家自然科学基金项目(81800716);广东省中医药局科研项目(20191065)。

摘　　要：目的观察黄连素和生活方式干预治疗糖尿病前期的疗效和预后。方法选取糖尿病前期患者70例,随机数字表法将其分为治疗组35例,对照组35例,对照组给予生活方式干预,治疗组在此基础上给予黄连素中医治疗,连续干预6个月。观察两组治疗前后血糖、糖化血红蛋白及血脂的差异。结果干预后6个月,治疗组总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗组空腹血糖、餐后2 h血糖、糖化血红蛋白、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、胰岛素抵抗指数、胰岛素运动指数及差值均明显高于对照组,差异均有统计学意义(均P<0.05);两组高密度脂蛋白胆固醇比较差异无统计学意义(均P>0.05)。结论应用黄连素和生活方式干预糖尿病前期,有助于改善糖尿病前期患者的血糖及血脂,预防和延缓糖尿病发生,改善病情严重程度和预后。Objective To investigate the effect and prognosis of berberine and lifestyle intervention on the treatment of pre-diabetic patients.Methods From January to August 2018,in Health Clinic,Endocrinology Clinic and Cardiology Clinic,the First Affiliated Hospital,Sun Yat-sen University,70 pre-diabetic patients were selected and were divided into control group and treatment group according to the random number table method,with 35 cases in each group.The duration of treatment was 6 months.The control group was given lifestyle intervention,while the treatment group was given berberine on the basis of traditional Chinese medicine treatment.The differences in blood sugar,glycosylated hemoglobin and blood lipid before and after treatment between the two groups were observed.Results After 6-month intervention,the total effective rate in the treatment group was 85.7%,15 cases were remarkably effective,15 cases were effective.The total effective rate in the control group was 62.9%,1 case was remarkably effective,21 cases were effective.The levels of fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin,triglyceride,total cholesterol,low density lipoprotein,insulin resistance index,insulin motor index after intervention and the above indexes differences between before and after intervention in treatment group were better than those of control group(P<0.05).There was no significant difference in the high density lipoprotein between the two groups(P>0.05).Conclusions Application of berberine and lifestyle intervention in pre-diabetes could improve fasting blood sugar,postprandial blood sugar,glycosylated hemoglobin and blood lipids,prevent and delay the occurrence of diabetes,and improve the severity and prognosis of pre-diabetes.

关 键 词：黄连素 生活方式 糖尿病前期 

分 类 号：R587.1[医药卫生—内分泌]