胰岛素联合阿卡波糖对继发性磺脲类药物失效的老年2型糖尿病的疗效  

Therapeutic effect of insulin glargine combined with acarbose in the treatment of type 2 diabetes mellitus patients

作　　者：周娟[1] 陈荣浩[1] 石春晖[1] 朱珠[1] 黄勇[1] 彭芳书 ZHOU Juan;CHEN Ronghao;SHI Chunhui;ZHU Zhu;HUANG Yong;PENG Fangshu(Department of Endocrinology,Danyang People′s Hospital,Danyang 212300,China;Department of Internal Medicine,Taihu Sanatorium of Jiangsu Province,Wuxi 214086,China)

机构地区：[1]丹阳市人民医院内分泌科,丹阳212300 [2]江苏省太湖疗养院内科,无锡214086

出　　处：《西北药学杂志》2021年第2期296-299,共4页Northwest Pharmaceutical Journal

基　　金：江苏省卫生计生委科研课题(编号:BJ16032)。

摘　　要：目的分析甘精胰岛素联合阿卡波糖片对继发性磺脲类药物失效的老年2型糖尿病患者的临床疗效。方法收集继发性磺脲类药物失效的老年2型糖尿病患者168例,将其随机分为观察组(82例)与对照组(86例),观察组采用甘精胰岛素联合阿卡波糖片治疗,对照组单独采用甘精胰岛素治疗,对2组患者治疗前后的体质量指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FIns)、空腹C肽值和胰岛素分泌指数(HOMA-IS)进行分析,并对2组患者的血糖达标时间、胰岛素用量、临床疗效和不良反应发生情况进行比较。结果治疗后2组患者的BMI、FBG和HbA1c值较治疗前降低,2组患者的空腹C肽值均升高,观察组的FIns值较治疗前升高,对照组的FIns值较治疗前降低,治疗后观察组的FBG和HbA1c值较对照组低,FIns和空腹C肽值较对照组高,差异均具有统计学意义(P<0.05);2组患者治疗后的β细胞功能指数(HOMA-β)较治疗前均增加,观察组患者治疗后的HOMA-IS较治疗前增加,差异具有统计学意义(P<0.05);观察组患者的血糖达标时间、胰岛素用量短(低)于对照组,总有效率(87.8%)高于对照组(66.3%),差异均具有统计学意义(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论甘精胰岛素联合阿卡波糖片治疗继发性磺脲类药物失效的老年2型糖尿病患者的临床效果更好,更有利于血糖的控制,未增加不良反应发生率。Objective To analyze the theraneutic effect of insulin glargine combined with acarbose in the treatment of type 2 diabetes mellitus with secondary sulfonylurea failure.Methods 168 elderly patients who diagnosed with type 2 diabetes mellitus patients with secondary sulfonylurea failure,were divided into observation group(82 cases)and control group(86 cases).The observation group was treated with insulin glargine and Acarbose Tablets,while the control group was treated with insulin glargine alone,then the body mass index(BMI),fasting blood glucose(FBG),hemoglobin A1c(HbA1c),fasting insulin(FIns),fasting C peptide and homeostasis model assessment-insulin secretion(HOMA-IS)of the 2 groups before and after treatment were analyzed.The time of reaching the standard of blood glucose,the dosage of insulin,the clinical effect and the occurrence of adverse reactions between the 2 groups were compared.Results After treatment,BMI,FBG and HbA1c of the 2 groups were lower than those before treatment,while FIns in the observation group were higher than that before treatment.The fasting C-peptide values of both groups were increased,while FIns in the control group were lower than that before treatment.After treatment,the FBG and HbA1c values in the observation group were lower than those in the control group,while the FIns and fasting C peptide values were higher than those in the control group,the differences were statistically significant(P<0.05).The homeostasis model assessment-β(HOMA-β)value of the 2 groups increased after treatment,the HOMA-IS value in the observation group after treatment was higher than that before treatment,the differences were statistically significant(P<0.05).The time of reaching the standard of blood glucose and the dosage of insulin in the observation group were lower than those in the control group,and the total effective rate(87.8%)was higher than that in the control group(66.3%),the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse

关 键 词：2型糖尿病 甘精胰岛素 阿卡波糖 继发性磺脲类药物失效 

分 类 号：R977[医药卫生—药品]