塞来昔布和抗骨质增生片对青海省成人大骨节病患者尿中PYD和DPD含量的影响  

Effects of celecoxib and anti-osteogenesis tablets on urinary excretion of PYD and DPD in adult Kashin-Beck disease patients in Qinghai Province

作　　者：樊迪 李强[2] 赵志军[2] Fan Di;Li Qiang;Zhao Zhijun(Department of Public Health,Medical College of Qinghai University,Xining 811602,China;Department for Endemic Disease Prevention and Control,Qinghai Institute for Endemic Disease Prevention and Control,Xining 811602,China)

机构地区：[1]青海大学医学院公共卫生系,西宁811602 [2]青海省地方病预防控制所地方病预防控制科,西宁811602

出　　处：《中华地方病学杂志》2021年第3期186-189,共4页Chinese Journal of Endemiology

基　　金：2017年度青海省基础研究项目(2017-ZJ-770);2017年度青海省卫生与计划生育委员会指导性课题(2017-wjzdx-38)。

摘　　要：目的探讨塞来昔布和抗骨质增生片对青海省成人大骨节病患者尿中生物标志物吡啶啉(PYD)和脱氧吡啶琳(DPD)的影响,为成人大骨节病治疗效果判定提供科学依据。方法根据《大骨节病诊断》(WS/T 207-2010),2017年7月,采用横断面调查方法在青海省大骨节病病区选取成人大骨节病病例120人,采用成组设计将其分为非药物治疗组(n=66)和药物治疗组(n=54),同时选取健康成人89人作为对照组,药物治疗组使用塞来昔布和抗骨质增生片治疗6个月。采集3组人群晨尿,使用酶联免疫吸附试验(ELISA)法检测尿中PYD和DPD含量,检测结果用肌酐(Cre)校正。结果非药物治疗组、药物治疗组和对照组间性别比例、年龄比较,差异均无统计学意义(χ2=0.820,F=0.379,P均>0.05)。3组人群尿中PYD中位数分别为1106.39、812.18、702.53 ng/μmol Cre,DPD中位数分别为1325.58、802.54、752.38 ng/μmol Cre,3间组比较差异均有统计学意义(H=13.849、34.621,P均<0.01),药物治疗组PYD、DPD含量均低于非药物治疗组(P均<0.05)。结论塞来昔布和抗骨质增生片可使成人大骨节病患者尿中PYD和DPD水平降低。Objective To investigate the effects of celecoxib and anti-osteogenesis tablets on urinary biomarkers pyridinoline(PYD)and deoxypyridinoline(DPD)in adult patients with Kashin-Beck disease(KBD)in Qinghai Province,and to provide scientific basis for treatment of adult KBD.Methods According to the"Diagnosis of Kaschin-Beck disease"(WS/T 207-2010),in July 2017,120 cases of adult KBD that were selected from the KBD area in Qinghai Province were divided into non-drug treatment group(n=66)and drug treatment group(n=54),and 89 healthy adults were selected as control group.The drug treatment group was taken celecoxib and anti-osteogenesis tablets for 6 months.Morning urine samples were collected from the three groups.The contentss of PYD and DPD in urine were detected by enzyme linked immunosorbent assay(ELISA),and the test results were corrected with creatinine(Cre).Results There were no statistically significant differences in gender ratio and age among non-drug treatment group,drug treatment group and control group(χ2=0.820,F=0.379,P>0.05).The medians of urinary PYD in the three groups were 1106.39,812.18,702.53 ng/μmol Cre,and the medians of DPD were 1325.58,802.54,752.38 ng/μmol Cre,respectively.The differences were statistically significant among the three groups(H=13.849,34.621,P<0.01).The contents of PYD and DPD in drug treatment group were lower than those in non-drug treatment group(P<0.05).Conclusion Celecoxib and anti-osteogenesis tablets can reduce the urinary levels of PYD and DPD in adult patients with KBD.

关 键 词：地方性变形性骨关节炎 吡啶啉 脱氧吡啶啉 

分 类 号：R684.1[医药卫生—骨科学]