生金理肺方联合噻托溴铵喷雾吸入治疗脾肺气虚型慢性阻塞性肺疾病稳定期临床疗效观察  

Clinical efficacy observation of Shengjin Lifei Formula combined with Tiotropium Bromide Spray inhalation treating patients with stable chronic obstructive pulmonary disease in syndrome of spleen-lung qi deficiency

作　　者：张传涛[1] 黄青松[2] 高培阳[1] 肖玮[1] 谢晓红[1] 陈科伶[1] 周鹏程[1] 孙增涛[1] 唐文君[1] 王武军[1] ZHANG Chuan-tao;HUANG Qing-song;GAO Pei-yang;XIAO Wei;XIE Xiao-hong;CHEN Ke-ling;ZHOU Peng-cheng;SUN Zeng-tao;TANG Wen-jun;WANG Wu-jun(Teaching Hospital of Chengdu University of TCM,Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院,成都610072 [2]成都中医药大学附属医院呼吸科,成都610072

出　　处：《中华中医药杂志》2021年第3期1757-1760,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：四川省科技厅项目(No.2020JDRC0114,No.2020YFH0164);成都中医药大学“杏林学者”计划(No.XSGG2019016,No.XGZX2003,No.JSZX005);成都中医药大学附属医院科技基金(No.19SX01,No.19YY10,No.19LW11,No.18ZL05);全国中医药创新骨干人才培训项目(No.国中医药办人教函[2019]128号);成都中医药大学附属医院“百人计划”项目(No.院办发[2020]42)。

摘　　要：目的:观察生金理肺方联合噻托溴铵喷雾吸入治疗脾肺气虚型慢性阻塞性肺疾病(COPD)稳定期患者的临床疗效。方法:54例COPD稳定期患者随机分为对照组和试验组,对照组给予噻托溴铵喷雾剂,试验组给予噻托溴铵喷雾剂+生金理肺方,两组患者疗程均为1个月。治疗前后观察患者中医证候积分、肺功能(FEV1、FEV1%、FEV1/FVC)、BODE相关指数[体质量指数(BMI)、FEV1%、呼吸困难程度(mMRC)、6分钟步行距离(6MWD)]等变化。结果:治疗后两组患者中医证候疗效、FEV1、FEV1%、6MWD、mMRC及治疗组FEV1/FVC、BMI显著改善(P<0.05),且试验组各指标优于对照组(P<0.05)。结论:生金理肺方不仅可以明显改善患者临床症状及肺功能,还能增加患者体质量,提高患者运动耐力,五行"生金"理论可有效运用于治疗稳定期COPD脾肺气虚型患者,值得临床推广。Objective: To observe the clinical efficacy of Shengjin Lifei Formula combined with Tiotropium Bromide Spray treating patients with stable chronic obstructive pulmonary disease(COPD) in syndrome of spleen-lung qi deficiency. Methods: Fifty-four patients with stable COPD were randomly divided into control group and test group. Patients in the control group were treated with Tiotropium Bromide Spray. Patients in the test group were treated with Tiotropium Bromide Spray and Shengjin Lifei Formula, the two groups of patients were treated for 1 month. Before and after treatment, the TCM syndrome scores, pulmonary function(FEV1, FEV1%, FEV1/FVC), BODE-related index [body mass index(BMI), FEV1%, modified medical research council scale(mMRC), 6-minute walk distance(6 MWD)] were observed respectively. Results: After treatment, the following indicators including TCM syndrome efficacy, FEV1, FEV1%, 6 MWD, mMRC were significantly improved in two groups, as well as FEV1/FVC and BMI in the test group(P<0.05). And all the above indicators in the test group were superior to the control group(P<0.05). Conclusion: Shengjin Lifei Formula can not only improve the clinical symptoms and lung function of patients, but also increase the body weight of patients and improve their exercise endurance. The ’Wu Xing generating metal’ theory can effectively treat stable COPD in syndrome of spleen-lung qi deficiency, which is worthy of clinical promotion.

关 键 词：五行生金 慢性阻塞性肺疾病 稳定期 临床疗效 生金理肺方 肺功能 脾肺气虚 

分 类 号：R563.9[医药卫生—呼吸系统]