尼可地尔对STEMI患者经PCI后无复流现象、心肌再灌注损伤及心功能影响的研究  

Study on the Effect of Nicorandil on no Reflow Phenomenon,Myocardial Reperfusion Injury and Cardiac Function in Patients With STEMI After PCI

作　　者：林勤英 LIN Qinying(Electroencephalogram Room,Chaonan Minsheng Hospital ofShantou,Shantou Guangdong 515144,China)

机构地区：[1]汕头潮南民生医院心脑电图室,广东汕头515144

出　　处：《中国卫生标准管理》2021年第6期110-112,共3页China Health Standard Management

摘　　要：目的探讨尼可地尔对ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)后无复流现象、心肌再灌注损伤及心功能的影响研究。方法选择2018年7月—2019年10月我院收治的118例STEMI,所有患者均接受PCI治疗,对照组行PCI治疗,研究组则在对照组基础上加用尼可地尔治疗,对比两组患者的疗效差异。结果手术前,研究组与对照组的心功能、心肌肌钙蛋白I(cardiac troponin-I,cTnI)、肌酸激酶同工酶(Creatine Kinase-MB,CK-MB)水平差异无统计学意义(P>0.05);治疗后,研究组的LVEF高于对照组,LVEDD低于对照组。手术后6 h、24 h,研究组的cTnI、CK-MB水平均低于对照组,研究组无复流现象发生率低于对照组(P>0.05)。结论STEMI患者PCI治疗中加用尼可地尔,能有效的改善患者的心功能,改善心肌再灌注损伤,降低无复流现象发生率。Objective To investigate the effects of nicorandil on no-reflow phenomenon,myocardial reperfusion injury and cardiac function in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods 118 cases of STEMI admitted to our hospital were included.All patients were treated with PCI from July 2018 to October 2019.The control group was treated with PCI,while the study group was treated with nicorandil on the basis of the control group.The curative effects of the two groups were compared.Results Before operation,there was no significant difference in cardiac function,cardiac troponin-I(CTNI)and Creatine Kinase-MB,CK-MB(CK-MB)levels between the study group and the control group(P>0.05).After treatment,LVEF of the study group was higher than that of the control group,and LVEDD was lower than that of the control group.At 6 h and 24 h after operation,the levels of cTnI and CK-MB in the study group were lower than those in the control group,and the incidence of no-reflow phenomenon in the study group was lower than that in the control group(P>0.05).Conclusion The addition of nicorandil in PCI treatment of STEMI patients can effectively improve the cardiac function of patients,improve myocardial reperfusion injury and reduce the incidence of no-reflow phenomenon.

关 键 词：尼可地尔 ST段抬高型心肌梗死患者 经皮冠状动脉介入治疗 无复流现象 心肌再灌注损伤 心功能 

分 类 号：R972[医药卫生—药品]