线粒体相关内质网膜在卵母细胞成熟中的作用  

Role of Mitochondrial Associated Endoplasmic Reticulum in Oocyte Maturation

作　　者：滕明明 高蕾蕾 雷安民[1] TENG Ming-Ming;GAO Lei-Lei;LEI An-Min(College of Veterinary Medicine,Shaanxi Stem Cell Engineering and Technology Research Center,Northwest A&F University,Yangling 712100,China)

机构地区：[1]西北农林科技大学动物医学院/陕西省干细胞工程技术中心,杨凌712100

出　　处：《农业生物技术学报》2021年第2期385-392,共8页Journal of Agricultural Biotechnology

基　　金：国家转基因生物新品种培育重大专项(2016ZX08006-003)。

摘　　要：线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membrane, MAM)是细胞内线粒体与内质网间的物理偶联结构,在调节线粒体动力学、钙信号传递、脂质加工与运输、线粒体自噬以及内质网应激等过程中都发挥着关键作用,MAM的这些生理功能对于卵母细胞的成熟是十分重要的。近年来研究发现,MAM上的多种蛋白参与了卵母细胞的成熟过程。本文综述了国内外近年来MAM相关蛋白参与卵母细胞成熟过程的研究进展,为了解卵母细胞成熟调控机制、卵母细胞质量鉴定以及提高辅助生殖成功率提供新的思考方向。The specific sites of physical association between endoplasmic reticulum(ER) and mitochondria are known as mitochondria-associated endoplasmic reticulum membrane(MAM), which plays an important role in the regulation of mitochondrial dynamics, calcium signaling, lipid processing and transportation,mitochondrial autophagy and endoplasmic reticulum stress. These physiological functions of MAM are very important for oocyte maturation. It has recently become clear that many proteins in MAM are crucial for oocyte maturation. This article reviews the research progress of MAM involved in oocyte maturation in recent years in order to provide a new direction for understanding the regulation mechanism of oocyte maturation,oocyte quality identification and improving the success rate of assisted reproduction.

关 键 词：线粒体相关内质网膜 卵母细胞成熟 线粒体动力学 钙离子转运 

分 类 号：S857.2[农业科学—临床兽医学]