衰老的分子机制及相关代谢组学研究  

Molecular mechanism of aging and related metabolomics research

作　　者：刘玥辰 阎星旭 赵换 孙桂江[2] 李遇伯[1] LIU Yuechen;YAN Xingxu;ZHAO Huan;SUN Guijiang;LI Yubo(College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Nephrology Blood Purification Treatment,Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天津医科大学第二医院肾脏病血液净化治疗科,天津300211

出　　处：《天津中医药大学学报》2021年第2期267-272,共6页Journal of Tianjin University of Traditional Chinese Medicine

摘　　要：衰老是机体水平自发的一种必然过程,也是疾病发生发展的常见危险因素。理解衰老的分子机制和发展过程是十分必要的,随着时间的推移,生物体内适应性的降低,衰老特征与不良的代谢变化有关,这表明存在控制衰老的"代谢时钟"。代谢组学可以很好地展示潜在的生物标志物及代谢途径的变化。通过阐述衰老的分子机制以及基于代谢组学的中药抗衰老研究,探讨中药抗衰老的研究进展,为临床抗衰老提供更多的研究思路,这样才让人们达到无病理的高龄,获得最佳的生活质量。Aging is an inevitable process of spontaneity at the body level,and it is also a common risk factor for the development of disease.It is necessary to understand the molecular mechanism and development process of aging.Over time,the body’s adaptability decreases,and aging characteristics are associated with adverse metabolic changes.This suggests that there is a“metabolic clock”that controls aging.Metabolomics can very well show us potential changes in biomarkers and metabolic pathways.By elaborating the molecular mechanism of aging and the study of Chinese medicine anti-aging based on metabolomics.Discuss the research progress of Chinese medicine anti-aging,provide more research ideas for clinical anti-aging,only in this way can people reach the advanced age without pathology and obtain the best quality of life.

关 键 词：衰老 分子机制 代谢组学 中药抗衰老 

分 类 号：R333.6[医药卫生—人体生理学]