幽门螺杆菌粪便抗原检测与尿素呼气试验对比研究  

Comparative Study of Helicobacter Pylori Stool Antigen Detection and Urea Breath Test

作　　者：张鹏飞 王明亚 ZHANG Peng-fei;WANG Ming-ya(Department of Internal Medicine,Benniu People's Hospital,Xinbei District,Changzhou,Jiangsu Province,213131 China)

机构地区：[1]常州市新北区奔牛人民医院内科,江苏常州213131

出　　处：《世界复合医学》2021年第2期73-75,共3页World Journal of Complex Medicine

摘　　要：目的对比幽门螺杆菌粪便抗原检测与尿素呼气试验对幽门螺杆菌(Hp)的检出效果,并对其应用价值进行分析。方法选择2019年3月—2020年3月在该院进行Hp检测的患者,对215例患者采用Hp粪便抗原检测(HpSA),其中阳性患者再给予Hp尿素呼气试验(^(13)C-UBT)进行检测,对比两种检测方式的检测效果。结果HpSA的阳性检出率为86.0%(185/215),而^(13)C-UBT的阳性检出率为80.5%(149/185),此外,HpSA与13C-UBT检测结果中出现的假阴性例数分别为8例、9例,经卡方检验;^(13)C-UBT的敏感性及特异性分别为93.8%与100.0%,HpSA检测方式的敏感性及特异性分别为92.4%与96.6%,二者具有高度的一致性(Kappa系数敏感性=0.89;Kappa系数特异性=0.87;均在0.8~1之间)。结论13C-UBT与HpSA两种检测方式均可获得理想的检测效果,但HpSA检测的使用范围更广,可有效弥补13C-UBT在老年人、婴幼儿等配合度较低患者中的应用缺陷,且不易受到组织病变的影响。Objective To compare the detection effect of Helicobacter pylori stool antigen test and urea breath test on Helicobacter pylori(Hp),and analyze its application value.Methods The patients who were tested for Hp in the hospital from March 2019 to March 2020 were selected.215 patients were tested for HP Stool Antigen Test(HpSA),and the positive patients were given Hp Urea Breath Test(13C-UBT)for testing,compare the detection effects of the two detection methods.Results The positive detection rate of HpSA was 86.0%(185/215),while the positive detection rate of^(13)C-UBT was 80.5%(149/185).In addition,the number of false negatives in the results of HpSA and 13C-UBT There are 8 cases and 9 cases respectivel;^(13)C-UBT sensitivity and specificity were 93.8%and 100.0%,respectively.The sensitivity and specificity of the HpSA detection method are 92.4%and 96.6%,respectively.The two had a high degree of consistency(Kappacoefficient sensitivity=0.89;Kappacoefficient specificity=0.87;both are between 0.8-1).Conclusion Both 13C-UBT and HpSA detection methods can achieve ideal detection results,but HpSA detection has a wider range of applications,which can effectively compensate for the application defects of^(13)C-UBT in the elderly,infants and other patients with low coordination,and it is not easy to be affected by tissue lesions.

关 键 词：幽门螺杆菌 粪便抗原检测 尿素呼气试验 

分 类 号：R446.6[医药卫生—诊断学] R57[医药卫生—临床医学]