布地奈德雾化吸入对早产儿支气管肺发育不良及1岁时智能发育的影响  

Effect of inhaled budesonide on the prevention of bronchopulmonary dysplasia in premature infants and its impact on the development of intelligence at 1 year old

作　　者：徐倩 张顺先 罗立荣 王红利 许敏鸿 余韶卫[1] XYU Qian;ZHANG Shunxian;LUO Lirong;WANG Hongli;XYU Minhong;YU Shaowei(Department of Pediatrics,Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University,Guangzhou 510523,China;Guangzhou Women′s and Children′s Medical Center,Guangzhou 510523,China)

机构地区：[1]暨南大学医学院附属广州市红十字会医院儿科,广州510523 [2]广州市妇女儿童医疗中心

出　　处：《公共卫生与预防医学》2021年第2期77-80,共4页Journal of Public Health and Preventive Medicine

基　　金：中国博士后基金项目(2018M643043)。

摘　　要：目的探讨布地奈德雾化吸入对早产儿支气管肺发育不良及1岁时的智能发育的影响。方法选择暨南大学医学院附属广州市红十字会医院2017年1月至2018年1月在新生儿重症监护中心住院的82例早产儿作为研究对象。采用随机数字表法将入组对象分为研究组(布地奈德)和对照组(生理盐水),每组各41例。比较两组患儿BPD的发生率、死亡率、住院时间、撤机及停氧时间、并发症,出院后定期随访至1岁,比较两组患儿的体格生长及Gesell智能发育评估。结果研究组BPD的发生率明显小于对照组,差异有统计学意义(P<0.05);两组死亡率比较差异无统计学意义(P>0.05);研究组住院时间、撤机及停氧时间、1周重新置管率均明显低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率及1岁时的体格生长及Gesell智能评估比较均无统计学意义。结论布地奈德雾化吸入可以降低早产儿BPD的发生率,缩短住院及撤机时间,而且无近远期不良反应。Objective To evaluate potential protective effects of inhaled budesonide on bronchopulmonary dysplasia(BPD)in premature infants and its impact on the intelligence development at 1 year of age.Methods A total of 82 preterm infants admitted to the neonatal intensive care center from January 2017 to January 2018 were selected as research subjects.The enrolled subjects were divided into a study group(Budesonide)and a control group(saline)by random number table method,with 41 cases in each group.The incidence of BPD,mortality,hospitalization time,time of withdrawal and oxygenation,and complications were compared between the two groups.The patients were regularly followed up to 1 year old after discharge.The physical growth and Gesell intelligence development of the two groups were compared.Results The incidence of BPD in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in mortality between the two groups.The hospitalization time,weaning and oxygenation time,and 1-week re-intubation rate in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference between the two groups in the incidence of adverse reactions and physical growth at 1 year old and Gesell intelligence evaluation.Conclusion Budesonide aerosol inhalation reduced the incidence of BPD in premature infants,shortened hospitalization and weaning time,and there were no near-term and long-term adverse reactions.

关 键 词：支气管肺发育不良 雾化吸入布地奈德 预防 神经发育 

分 类 号：R174[医药卫生—妇幼卫生保健]