CK-MB、cTnI、IL-10水平对小儿心肌炎的诊断价值研究  

Diagnostic Value of Creatine Kinase Isoenzyme(CK-MB),Cardiac troponin I(cTnI)and Interleukin-10(IL-10)Levels in Children with Viral Myocarditis

作　　者：任冲 杨冰 陈楠[1] Ren Chong;Yang Bing;Chen Nan(Affiliated Children's Hospital of Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Key Laboratory of Child Infection and Immunity in Zhengzhou,Zhengzhou 450000)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院,郑州市儿童感染与免疫重点实验室,郑州450000

出　　处：《数理医药学杂志》2021年第4期475-478,共4页Journal of Mathematical Medicine

摘　　要：目的:研究肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、白介素10(IL-10)水平对小儿病毒性心肌炎的诊断价值。方法:选择2018年9月~2019年4月间某院收治的40例病毒性心肌炎患儿作为观察组,另选择该时段内体检的40例健康儿童作为对照组,对比两组儿童血清中CK-MB、cTnI、IL-10水平,观察3种因子水平随小儿心肌炎病情分期的变化,分析3种因子单项诊断和联合诊断小儿心肌炎时的诊断价值。结果:观察组血清中CK-MB、cTnI、IL-10水平高于对照组(P<0.05);急性期小儿心肌炎患儿血清IL-10水平高于迁延期,迁延期IL-10水平高于慢性期(P<0.05);急性期、迁延期、慢性期小儿心肌炎患儿血清CK-MB、cTnI水平比较,差异无统计学意义(P>0.05);血清中CK-MB、cTnI、IL-10联合诊断AMI的曲线下方面积(AUC)为0.828,高于CK-MB(0.676)、cTnI(0.799)、IL-10(0.592)(P<0.05)。结论:检测血清CK-MB、cTnI、IL-10水平对临床诊断小儿心肌炎有较大帮助,能体现病情发展不同阶段炎症反应的进展程度,3种因子联合检测有较高诊断价值。Objective:To investigate the diagnostic value of creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI)and interleukin-10(IL-10)levels in children with viral myocarditis.Methods:Forty children with viral myocarditis admitted to a hospital from September 2018 to April 2019 were selected as the observation group.In addition,40 healthy children who received physical examination in a hospital during the same period were selected as the control group.The levels of CK-MB,cTnI and IL-10 in the serum of the two groups were compared to observe the changes of the levels of the three factors with the stage of childhood myocarditis,and the diagnostic value of the three factors in the single diagnosis and combined diagnosis of pediatric myocarditis was analyzed.Results:The serum levels of CK-MB,cTnI and IL-10 in the observation group were higher than those in the control group(P<0.05).The serum IL-10 level in children with acute myocarditis was higher than that in the delayed stage,while the IL-10 level in the delayed stage was higher than that in the chronic stage(P<0.05).The serum levels of CK-MB and cTnI in children in acute stage,delayed stage and chronic stage were not statistically significant(P>0.05).The area under the curve(AUC)of serum CK-MB,cTnI and IL-10 in the combined diagnosis of AMI was 0.828,higher than that of CK-MB(0.676),cTnI(0.799)and IL-10(0.592)(P<0.05).Conclusion:The detection of serum CK-MB,cTnI and IL-10 levels is of great help in the clinical diagnosis of pediatric myocarditis,and can reflect the progression of inflammatory response at different stages of disease development.Combined detection of the three factors is of high diagnostic value.

关 键 词：病毒性心肌炎 肌酸激酶同工酶 心肌肌钙蛋白I 白介素10 

分 类 号：R725.4[医药卫生—儿科]