保胆取石术后口服牛磺熊去氧胆酸预防结石复发的疗效与价值评估  

Evaluation of efficacy and value of oral tudca in preventing stone recurrence after choledocholithiasis

作　　者：雷林瑜[1] 李文奇[1] 张俊杰[1] LEI Lin-yu;LI Wen-qi;ZHANG Jun-jie(Zhengzhou People's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院普外三科,郑州450000

出　　处：《医药论坛杂志》2021年第4期51-54,共4页Journal of Medical Forum

摘　　要：目的探讨保胆取石术后口服牛磺熊去氧胆酸预防结石复发的疗效与价值。方法选取2018年4月—2020年4月期间郑州人民医院普外三科收治的80例胆结石患者为研究对象,患者均行保胆取石术治疗,采用双色球抽签的方式将患者分至两组中,其中抽取红色球及绿色球的患者分别分至对照组与观察组中,每组各40例,对照组术后口服熊去氧胆酸治疗,观察组术后口服牛磺熊去氧胆酸治疗,对比两组患者术后2年胆囊壁厚度及胆囊收缩功能,记录患者不同时期结石复发率及症状复发率。结果术前观察组胆囊厚度(3.16±0.69)mm较对照组胆囊壁厚度(3.18±0.72)mm无统计学意义(P>0.05)。术后2年两组患者的胆囊壁厚度均得以减小,观察组减小幅度(0.58±0.12)mm大于对照组减少幅度(0.14±0.05)mm,且差异具有统计学意义(P<0.05)。术后2年两组患者胆囊收缩功能对比,观察组胆囊排空指数(56.32±10.58)明显优于对照组胆囊排空指数(45.65±14.34),差异具有统计学意义(P<0.05)。随访2年观察组结石复发率(12.50%)低于对照组结石复发率(32.50%),差异具有统计学意义(P<0.05)。观察组症状复发率(7.50%)低于对照组(12.50%),差异无统计学意义(P>0.05)。结论术后口服牛磺熊去氧胆酸能改善胆囊收缩功能,缩小胆囊壁厚度,减少保胆取石术后结石复发及症状复发的情况,具有极高的临床使用价值。Objective To explore the curative effect and value of taking tudca orally to prevent recurrence of stones after choledocholithiasis.Methods Totally 80 patients with gallstones admitted to the general surgery department of zhengzhou people’s hospital from April 2018 to April 2020 were selected as the research objects. All patients were treated with cholelithiasis. The patients were divided into two groups by drawing lots with two color balls. The patients with red balls and green balls were divided into control group and observation group, with 40 cases in each group. The control group was treated with ursodeoxycholic acid after operation, while the observation group was treated with tudca after operation. The gallbladder wall thickness and gallbladder contractile function of the two groups were compared 2 years after operation.Results The thickness of the gallbladder in the observation group(3.16±0.69) mm was not statistically significant compared with the thickness of the gallbladder wall in the control group(3.18±0.72) mm(P>0.05). Two years after the operation, the thickness of the gallbladder wall of the two groups of patients was reduced. The reduction in the observation group(0.58±0.12) mm was greater than the reduction in the control group(0.14±0.05) mm, and the difference was statistically significant(P<0.05). The gallbladder emptying index(56.32±10.58) of the observation group was significantly better than that of the control group(45.65±14.34). The difference was statistically significant(P<0.05). The recurrence rate of stones in the observation group(12.50%) was lower than that in the control group(32.50%) after a 2-year follow-up, and the difference was statistically significant(P<0.05). The recurrence rate of symptoms in the observation group(7.50%) was lower than that in the control group(12.50%), and the difference was not statistically significant(P>0.05).Conclusion Oral tudca can improve gallbladder contraction function, reduce gallbladder wall thickness, and reduce recurrence of stones an

关 键 词：保胆取石术 牛磺熊去氧胆酸 结石复发 疗效 

分 类 号：R657.4[医药卫生—外科学]