中药临方浓缩水丸的丸条物理性质表征方法研究  

Characterization of physical properties of pill strip in personalized concentrated watered pill of traditional Chinese medicine

作　　者：陈恒晋 张雪[1] 胡志强 林晓[2] 沈岚[2] 鲜洁晨[3] 张磊[1] 洪燕龙[1] CHEN Hengjin;ZHANG Xue;HU Zhiqiang;LIN Xiao;SHEN Lan;XIAN Jiechen;ZHANG Lei;HONG Yanlong(Shanghai Innovation Center of TCM Health Service,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Innovative Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中医健康服务协同创新中心,上海201203 [2]上海中医药大学中药学院,上海201203 [3]上海中医药大学创新中药研究院,上海201203

出　　处：《上海中医药大学学报》2021年第2期68-75,共8页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81973490);上海市自然科学基金资助项目(18ZR1436600);上海市“科技创新行动计划”技术标准项目(20DZ2200900);上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-2001-03]。

摘　　要：目的:建立中药临方浓缩水丸制备过程中制剂中间体丸条的物理性质表征方法。方法:以健脾丸为模型处方,基于课题组前期建立的临方浓缩水丸制备技术制备丸条,采用物性测定仪的质构曲线解析法测定压缩力、回复力、弹性、黏性等9个物理性质参数,单因素考察优选出表征丸条特征物理性质的测定条件,并进行方法学考察。以六味地黄丸、附子理中丸、保和丸为模型处方进行样品测定。结果:优选的测试参数如下:执行触发力7 g,第1次下压距离0.5 mm,第2次下压距离4.5 mm,测前速度0.1 mm/s,测试速度0.7 mm/s,测后速度0.5 mm/s。在此条件下,丸条各项物理性质参数的相对标准偏差均<15%。结论:该方法表征丸条的多个物理性质具有较好的精密度、准确性和适用性。Objective: To establish the characterization method for physical properties of strip of pill in the preparation process of personalized concentrated watered pill. Methods: Jianpi Pill was taken as the model recipe, and the strip of pill was prepared based on preparation technology of personalized concentrated watered pills, which established by our research group in the early stage. Using texture analyzer, nine physical property parameters, such as compression force, restoring force, elasticity and viscosity, were determined by texture profile analysis. The determination conditions for characteristic physical properties of pill strip were optimized by single factor method, and the methodology was investigated. Liuwei Dihuang Pill, Fuzi Lizhong Pill and Baohe Pill as the model recipes were determined. Results: The optimized determination parameters were as follows: trigger force was 7 g, first compression distance was 0.5 mm, second compression distance was 4.5 mm, pre-test speed was 0.1 mm/s, test speed was 0.7 mm/s, and post-test speed was 0.5 mm/s. Under these conditions, the relative standard deviations of all physical property parameters of pill strip were less than 15%. Conclusion: The established method shows good precision, accuracy and applicability in characterizing multiple physical properties of pill strip.

关 键 词：中药临方制剂 浓缩水丸 丸条 物理性质 质构曲线解析法 健脾丸 

分 类 号：R283.6[医药卫生—中药学]