大动物节段性骨缺损模型的研究进展  

Research progress of segmental bone defect models in large animals

作　　者：陈胡贵 覃建国 李理[1] 石展英[1] 潘浩波 李兵[1] 崔旭 CHEN Hugui;QIN Jianguo;LI Li;SHI Zhanying;PAN Haobo;LI Bing;CUI Xu(Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’Hospital,Liuzhou,Guangxi Zhuang Autonomous Region 545005;Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong Province 518055)

机构地区：[1]广西医科大学第四附属医院/柳州市工人医院,广西柳州545005 [2]中国科学院院深圳先进技术研究院,广东深圳518055

出　　处：《北京生物医学工程》2021年第2期203-208,共6页Beijing Biomedical Engineering

基　　金：国家自然科学基金(81860385、51802340);广西重点研发计划项目(桂科AB17129001);柳州市科技计划科技重大专项(2018AF10504);柳州市科学研究与技术开发计划(2017BH20308)资助。

摘　　要：四肢节段性骨缺损,尤其是临界尺寸节段性骨缺损的修复仍然是骨科最具挑战性的难题之一。人工骨材料逐渐取代自体骨及同种异体骨成为骨缺损修复的研究热点。为评价人工骨材料作为骨缺损修复替代物的发展前景,有必要建立可重复且有效的节段性骨缺损动物模型,但目前尚无一种理想的大动物节段性骨缺损模型能完美模拟人类骨结构和力学特征。因此本文对大动物节段性骨缺损模型的临界尺寸骨缺损大小的取值、常用建模动物的优缺点、节段性骨缺损模型的建立、骨材料的不同固定方法等方面进行综述,以促进大动物节段性骨缺损模型的优化改进。The repair of segmental bone defects of extremities,especially those of critical size,is still one of the most challenging problems in orthopaedics.Artificial bone has gradually replaced autogenous bone and allogeneic bone to become the research focus of bone defect repair.In order to evaluate the development of artificial bone as a substitute for repairing bone defects,it is necessary to establish a reproducible and effective animal model of segmental bone defects.However,there is not an ideal model of segmental bone defects in a large animal that can perfectly simulate human bone structure and mechanical characteristics.Therefore,this article reviews the critical size of bone defect,the advantages and disadvantages of different modeling animals,the establishment of segmental bone defect model in large animals,and the different fixation methods of bone materials,to improve the model of segmental bone defect in large animals.

关 键 词：节段性骨缺损 生物材料 骨缺损修复 动物模型 

分 类 号：R318[医药卫生—生物医学工程]