马尔尼菲篮状菌与巨噬细胞相互作用机制研究进展  

Research Progress on the Interaction Mechanism Between Talaromyces Marneffei and Macrophages

作　　者：陈日凤 刘栋华[1] CHEN Rifeng;LIU Donghua(Department of Dermatology and Venereology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院皮肤性病科,广西南宁530021

出　　处：《中国皮肤性病学杂志》2021年第4期459-463,共5页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金(81760564)。

摘　　要：马尔尼菲篮状菌是一种重要的机会致病菌,能在宿主巨噬细胞内存活。马尔尼菲篮状菌与宿主巨噬细胞的初始相互作用以及宿主对马尔尼菲篮状菌固有免疫反应的激活程度是宿主控制感染的关键因素。马尔尼菲篮状菌在与宿主巨噬细胞的长期相互作用过程中,逐渐形成多种逃避巨噬细胞杀伤作用的机制。本文就马尔尼菲篮状菌与巨噬细胞相互作用研究进展进行综述。Talaromyces marneffei is an important opportunistic pathogen that can survive in host macrophages.The initial interaction between T.marneffei and host macrophages and degree of activation of the host's innate immune response to T.marneffei are key factors for host to control infection.During the long-term interaction with host macrophages,T.marneffei gradually adopts a variety of mechanisms to evade the toxic effect of macrophages.In this review,we summrised and reviewed the progression of interaction between T.marneffei and macrophages.

关 键 词：马尔尼菲篮状菌 巨噬细胞 相互作用 

分 类 号：R519[医药卫生—内科学]