美托洛尔联合丹参多酚治疗不稳定心绞痛的效果  

The Effect of Metoprolol and Salvia Polyphenols on Unstable Angina Pectoris

作　　者：赵智慧[1] 郑杰[1] ZHAO Zhihui;ZHENG Jie(Department of Cardiovascular Medicine,Tianyou Hospital,Wuhan University of Science and Technology,Wuhan Hubei 430064,China)

机构地区：[1]武汉科技大学附属天佑医院心血管内科,湖北武汉430064

出　　处：《中国继续医学教育》2021年第11期170-173,共4页China Continuing Medical Education

摘　　要：目的探索美托洛尔联合丹参多酚酸盐治疗对不稳定心绞痛患者血清MMP-9、HCY水平、血管内皮功能及心功能的影响。方法选择120例不稳定心绞痛患者为试验对象,选择单双号随机化分组,各60例,对照组采用美托洛尔治疗,观察组采用美托洛尔联合丹参多酚酸盐治疗,随后对比两组血管内皮素、金属基质蛋白酶9(MMP-9)、同型半胱氨酸(HCY)水平、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)。结果观察组MMP-9、HCY水平、血管内皮素、LVESD、LVEDD均低于对照组,LVEF高于对照组(P<0.05)。结论对不稳定心绞痛患者实施美托洛尔联合丹参多酚酸盐治疗效果显著,利于改善心功能和血管内皮功能。Objective To explore the effect of metoprolol combined with salvia miltiorrhiza polyphenolate on serum MMP-9,HCY levels,vascular endothelial function and cardiac function in patients with unstable angina.Methods 120 patients with unstable angina pectoris were selected as the test subjects,and randomized groups of single and double numbers were selected,60 cases in each group,the control group was treated with metoprolol,the observation group was treated with metoprolol combined with salvia polyphenolate,and then compared Endothelin,MMP-9,HCY level(homocysteine),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD).Results The levels of MMP-9,HCY,vascular endothelin,LVESD,and LVEDD of the observation group were lower than those of the control group,and LVEF was higher than that of the control group(P<0.05).Conclusion The effect of metoprolol combined with salvia miltiorrhiza polyphenolate in patients with unstable angina pectoris is significant,which is conducive to improving cardiac function and vascular endothelial function.

关 键 词：美托洛尔 丹参多酚酸盐 心绞痛 MMP-9 HCY 血管内皮功能 心功能 

分 类 号：R541[医药卫生—心血管疾病]