百草枯中毒患者的IL-6、sIL-6R、sgp130水平及其与患者预后的相关性分析  

Levels of IL-6,sIL-6R,sgp130 in patients with paraquat poisoning and their correlation analyses with the prognosis of patients

作　　者：李激文 黎宇[1] 邓旺生[1] 钟雨 LI Jiwen;LI Yu;DENG Wangsheng;ZHONG Yu(Department of Emergency,The Fourth Affiliated Hospital of Guangxi Medical University(Liuzhou Workers′Hospital),Liuzhou 545600,China)

机构地区：[1]广西医科大学第四附属医院(柳州市工人医院)急诊科,广西柳州市545600

出　　处：《内科》2021年第1期8-10,14,共4页Internal Medicine

基　　金：广西急诊与医学救援人才小高地、广西高校急诊医学重点实验室开放课题项目(GXJZ201623);广西卫生与计划生育委员会计划课题项目(Z2016181)。

摘　　要：目的探讨百草枯中毒患者的IL-6、sIL-6R、sgp130表达水平及其与患者预后的关系。方法选取2017年1月至2019年7月我院收治的百草枯中毒患者60例作为中毒组,选择同期来我院进行健康体检的志愿者60名为对照组。根据患者的预后情况将中毒组患者分为预后良好组(38例)和预后不良组(22例)。比较中毒组患者和对照组健康志愿者、预后良好组和预后不良组患者的血清IL-6、sIL-6R、sgp130水平;对中毒患者入院时的血清IL-6、sIL-6R、sgp130水平与其预后的关系进行Spearman相关性分析。结果百草枯中毒组患者的血清IL-6、sIL-6R、sgp130水平均显著高于对照组健康志愿者,预后良好组患者的血清IL-6、sIL-6R、sgp130水平均显著低于预后不良组患者,差异有统计学意义(P<0.05);中毒患者入院时的血清IL-6、sIL-6R、sgp130水平与其预后均呈负相关(r=-0.857,r=-0.720,r=-0.688,P均<0.05)。结论百草枯中毒患者的血清IL-6、sIL-6R、sgp130水平显著升高并与患者预后密切相关,有效降低患者血清IL-6、sIL-6R、sgp130水平或可阻止其肺损伤进一步加重、改善预后。Objective To explore the expression levels of IL-6,sIL-6R and sgp130 in patients with paraquat poisoning and their relationship with the prognosis of patients.Methods A total of 60 patients with paraquat poisoning admitted to our hospital from January 2017 to July 2019 were selected as the poisoning group,and 60 volunteers who came to our hospital for physical examination during the same period were selected as the control group.The patients in the poisoning group were divided into favorable prognosis group(38 cases)and poor prognosis group(22 cases)according to the prognosis of the patients.The serum IL-6,sIL-6R,and sgp130 levels were compared between patients in the poisoning group and healthy volunteers in the control group,the favorable prognosis group and the poor prognosis group.The Spearman correlation analysis was performed on the relationship between serum IL-6,sIL-6R,sgp130 levels and prognosis of poisoning patients.Results As compared with the healthy volunteers in the control group and the patients in the poor prognosis group,the poisoning group yielded higher levels of serum IL-6,sIL-6R and sgp130,whereas the favorable prognosis group yielded lower levels mentioned above,with statistically significant differences(P<0.05).The levels of serum IL-6,sIL-6R,and sgp130 in poisoned patients admitted to the hospital were negatively correlated with the prognosis of the patients(r=-0.857,r=-0.720,r=-0.688,all P<0.05).Conclusion The serum IL-6,sIL-6R,and sgp130 levels of patients with paraquat poisoning significantly increase,and they are closely related to the prognosis of the patients.Effectively decreasing the levels of serum IL-6,sIL-6R,and sgp130 in patients may prevent further lung injury in patients and improve their prognosis.

关 键 词：百草枯中毒 急性肺损伤 IL-6 SIL-6R SGP130 

分 类 号：R595[医药卫生—内科学]