57例甲型流感病毒感染合并肺炎患者感染指标与病毒载量相关性  

Correlation between infection indexes and viral load in 57 patients with influenza A virus infection complicated with pneumonia

作　　者：吴艳艳[1] 申瑶[1] 何全利 刘伟 陈晓霞 WU Yan-yan;SHEN Yao;HE Quan-li;LIU Wei;CHEN Xiao-xia(Department of Healthcare -associated Infection Management;Department of Clinical Laboratory;Department of Respiratory and Critical Care Medicine, People’s Hospital of Jiaozuo, Jiaozuo 454002, China)

机构地区：[1]焦作市人民医院感染管理科 [2]检验科 [3]呼吸与危重症学科,河南焦作454002

出　　处：《中国感染控制杂志》2021年第4期357-360,共4页Chinese Journal of Infection Control

摘　　要：目的分析流感高峰期甲型流感病毒感染且合并肺炎患者的临床表现特点。方法将2018年12月—2019年4月某院呼吸内科甲型流感病毒感染合并肺炎住院患者列为甲流合并肺炎组,内科门诊就诊的甲型流感病毒感染患者列为甲流组,体检中心正常体检者列为体检组,回顾性分析患者临床表现和特征。结果甲流合并肺炎组57例,甲流组42例,体检组33例,三组年龄比较,差异有统计学意义(F=16.57,P<0.001),甲流合并肺炎组患者年龄最大,为(61.65±16.92)岁。甲流合并肺炎组患者白细胞(WBC)计数中性粒细胞百分比以及C反应蛋白(CRP)、降钙素原(PCT)、血清淀粉样蛋白(SAA)检测值均高于甲流组患者和体检组健康者(均P<0.05)。甲流合并肺炎组患者甲型流感病毒载量核酸检测CT值(16.18±2.53)低于甲流组患者(19.30±4.12),差异有统计学意义(t=2.100,P=0.039);甲流合并肺炎组患者检测结果CT值与其感染指标CRP、PCT相关系数(r)分别为-0.51、-0.55,均呈负相关。结论甲型流感病毒感染患者为老年人,甲型流感病毒载量高,感染指标CRP、PCT升高提示感染者存在合并肺炎的风险,可为临床诊疗提供依据。Objective To analyze the clinical characteristics of patients with influenza A virus infection complicated with pneumonia during the peak period of influenza.Methods From December 2018 to April 2019,hospitalized patients with influenza A virus infection complicated with pneumonia in the respiratory department of a hospital were classified as influenza A complicated with pneumonia group,patients only with influenza A virus infection in internal medicine outpatient department were classified as influenza A group,and the healthy physical examinees in physical examination center were classified as physical examination group,clinical manifestations and characteristics of patients were retrospectively analyzed.Results There were 57 cases in influenza A complicated with pneumonia group,42 cases in influenza A group,and 33 in physical examination group,difference in age among three groups was significant(F=16.57,P<0.001).The age of patients in influenza A complicated with pneumonia group was the oldest,which was(61.65±16.92)years.White blood cell(WBC)count,neutrophil percentage,C-reactive protein(CRP),procalcitonin(PCT)and serum amyloid A protein(SAA)of patients in influenza A complicated pneumonia group were higher than those of patients in influenza A group and persons in physical examination group(all P<0.05).Cycle threshold(CT)value of influenza A virus load nucleic acid detection in patients in influenza A complicated with pneumonia group was lower than that in patients in influenza A group([16.18±2.53]vs[19.30±4.12],t=2.100,P=0.039);correlation coefficients(r)between CT value and CRP as well as PCT in patients in influenza A complicated with pneumonia group were-0.51 and-0.55 respectively,both were negatively correlated.Conclusion Patients with influenza A virus infection are elderly people with high influenza A virus load,the increase of CRP and PCT suggests the risk of pneumonia for patients with influenza A virus infection,which can provide the basis for clinical diagnosis and treatment.

关 键 词：甲型流感病毒 肺炎 病毒载量 临床特征 

分 类 号：R563.1[医药卫生—呼吸系统]