血小板在抵御细菌感染和增强免疫中的地位  

The role of platelet in resisting bacterial infection and enhancing immunity

作　　者：易观群(综述) 谢双锋[1] 马丽萍(审校)[1] YI Guan-qun;XIE Shuang-feng;MA Li-ping(Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China)

机构地区：[1]中山大学孙逸仙纪念医院血液内科,广东广州510120

出　　处：《中国感染控制杂志》2021年第4期374-380,共7页Chinese Journal of Infection Control

基　　金：广州市科技计划项目(民生科技攻关计划)(201803010012);广东省自然科学基金自由申请项目(2016A030313329)。

摘　　要：血小板具有止血和维持血管完整的基本功能,但近年研究证明其在细菌感染中担任重要的免疫防御角色。当机体出现细菌感染时,血小板第一个迁徙到感染前线,识别、捆绑、内吞病原菌或释放多种杀微生物蛋白直接杀灭细菌;同时增强中性粒细胞、单核细胞、补体系统的固有免疫功能,促T细胞、B细胞启动适应性免疫功能,协助共同清除机体细菌。Platelet has the basic function of hemostasis and maintaining vascular integrity,recent studies have proved that it plays an important role in immune defense against bacterial infection.When bacterial infection occurs,platelet firstly migrate to the infection frontline to identify,bind,endocytose pathogens or release a variety of platelet microbicidal protein,which can directly kill bacteria,strengthen the innate immune function of neutrophil,monocyte and complement system,promote T lymphocyte and B lymphocyte to initiate adaptive immune responses against bacteria.

关 键 词：血小板 细菌 感染 免疫 

分 类 号：R515[医药卫生—内科学] R446.11[医药卫生—临床医学]