ICP-MS分析不同产地黄连中39种无机元素  

Quantitative Analysis of 39 Inorganic Elements in Coptidis Rhizoma from Different Origins by ICP-MS

作　　者：周利[1] 康利平[1] 郝庆秀[1] 郭兰萍[1] 康传志 王升[1] 杨健[1] ZHOU Li;KANG Li-ping;HAO Qing-xiu;GUO Lan-ping;KANG Chuan-zhi;WANG Sheng;YANG Jian(State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药资源中心道地药材国家重点实验室培育基地,北京100700

出　　处：《中国现代中药》2021年第2期265-274,285,共11页Modern Chinese Medicine

基　　金：中央级公益性科研院所基本科研业务费专项(ZZXT201808,ZZXT201906);国家药典委员会药品医疗器械审评审批制度改革项目(ZG2016-1)。

摘　　要：目的:建立黄连中39种无机元素的含量分析方法,为黄连后续的相关研究提供参考。方法:采用微波高压消解法对样品进行消解,采用电感耦合等离子体质谱法(ICP-MS)对样品中39种无机元素的含量进行检测,并对检测方法进行方法学考察。结果:分析方法符合测定要求,67批次样品中K、Mg、Mn、Zn、Fe 5种元素的平均含量最高,稀土元素的含量则普遍较低。各产地黄连在遗传距离为10时,表现出了较好的产地聚集性特征。结论:该方法操作简便、快速、准确,结果可靠,适用于黄连中无机元素的含量分析。Objective:The content analysis method was established to analyze the 39 inorganic elements in the Coptidis Rhizoma from different origin,to provide a reference for the related research of Coptidis Rhizoma.Methods:The sample was digested by microwave high-pressure digestion method,and the content of 39 inorganic elements in Coptidis Rhizoma ware detected by inductively coupled plasma-mass spectrometry(ICP-MS),and the detection method was examined by methodology.Results:The methods of 39 inorganic elements were reasonable and effective by validation.The average contents of K,Mg,Mn,Zn and Fe in the 67 batches of samples were the highest,while the contents of rare earth elements are generally lower.Coptidis Rhizoma from all habitats showed good aggregation at a genetic distance of 10.Conclusion:The established method is simple with fast analysis and high sensitivity,and the method is suitable for determination of inorganic elements in Coptidis Rhizoma.

关 键 词：黄连 电感耦合等离子体质谱法 微波消解 无机元素 

分 类 号：R282[医药卫生—中药学]