磁性纳米材料在肿瘤靶向化疗中的研究进展  

Research advances in magnetic nanoparticle-based drug delivery for chemotherapy

作　　者：刘庆祖 杨慧恺 刘建恒[1] 刘重阳 毛克亚[1] LIU Qingzu;YANG Huikai;LIU Jianheng;LIU Chongyang;MAO Keya(Department of Orthopedics,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Anesthesiology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Jining Medical University,Jining 272000,Shandong Province,China)

机构地区：[1]解放军总医院第一医学中心骨科,北京100853 [2]解放军总医院第一医学中心麻醉科,北京100853 [3]济宁医学院,山东济宁272000

出　　处：《解放军医学院学报》2020年第12期1252-1255,1269,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金资助项目(51772328);国家自然科学基金青年基金项目(81702121);军队后勤重大项目子课题(AWS17J004);首发科研专项项目(首发2018-4-5014)。

摘　　要：化疗药物常借助静脉给药方式作用于人体脏器,但这种途径同时也对人的肝、肾等器官造成了不可逆的损伤。近年来,磁性纳米材料的研究进展迅速。以磁性纳米材料为基础的靶向载药系统与传统的化疗方法相比具有靶向性明确、缓释性强、生物利用度高等优点。本文综述了磁性纳米材料在肿瘤化疗药物靶向递送方面的应用进展,并分析了其面临的挑战及发展前景。Traditional chemotherapeutic drugs act on targeted organs through intravenous administration,causing irreversible damage to human liver and kidney while attacking tumor tissues.In recent years,researches on magnetic nanomaterials develop rapidly.After surface modification,magnetic nanomaterials have good biocompatibility,high drug loading capacity,and targeted aggregation under the effect of an external magnetic field,which have attracted the attention of researchers.Compared with traditional drugs,the magnetic nanoparticle-based drug delivery system has the features of specific targeting,slow-releasing,and high bioavailability.This article reviews the research progresses of magnetic nanomaterials in targeted delivery for chemotherapy.

关 键 词：磁性纳米材料 肿瘤化疗 靶向给药 磁热疗 栓塞化疗 

分 类 号：R943[医药卫生—药剂学]